Absorption of 125I-NPH insulin (125I-isophane insulin) (40 IU/ml) was studied in eight diabetics given 50% and 150% of their normal daily dose of insulin. Insulin absorption correlated with plasma insulin (r = 0.97, p less than 0.001) and blood glucose (r = -0.87, p less than ...
There was some crystal formation with both formulations, but less with insulin aspart. Patients who used aspart required a slightly higher basal dose of insulin but had fewer unexplained attacks of hypoglycemia. Frequent addition of isophane to a regimen of insulin aspart is unnecessary, as has ...
In normal subjects, approximately half of the daily insulin requirement constitutes basal insulin. We investigated whether increasing the dose of insulin glargine up to half of the total insulin requirement could lead to better glycemic control in type 2 diabetic patients who were treated on basal-pr...
Laboratory results were as follows: hemoglobin A1c 5.9%, c-peptide level was 0.3 ng/mL (normal range 0.8-3.9 ng/mL) with a glucose of 68 mg/dL (normal range 70-100 mg/dL), insulin 203.8 mcIU/mL (normal range less than 24 mcIU/mL), proinsulin 3.2 pmol/L (normal range less than...
Taking the premixed insulin out of the refrigerator, then withdrawing the amount into in one syringe. B. Using two syringes, one for each type of insulin, and giving two injections. C. Withdrawing the NPH insulin first, then withdrawing the regular insulin into one syringe. D. W...
Low-dose bedtime NPH insulin with daytime sulfonylurea in treatment of secondary failure to oral hypoglycemic agents in type II NIDDM patientsGedik, OBayraktar, MOzdemir, TAkalin, SAdalar, NUsman, ATelatar, F
Dose-dependent subcutaneous absorption of porcine, bovine and human NPH insulins.doi:10.1111/j.0954-6820.1984.tb04971.xPer HildebrandtKjeld BirchLeif SestoftAage VlundBlackwell Publishing Ltd
Laboratory results were as follows: hemoglobin A1c 5.9%, c-peptide level was 0.3 ng/mL (normal range 0.8-3.9 ng/mL) with a glucose of 68 mg/dL (normal range 70-100 mg/dL), insulin 203.8 mcIU/mL (normal range less than 24 mcIU/mL), proinsulin 3.2 pmol/L (normal range less than...
Intensive insulin therapyType 2 diabetesBasal-prandial insulin therapyIn normal subjects, approximately half of the daily insulin requirement constitutes basal insulin. We investigated whether increasing the dose of insulin glargine up to half of the total insulin requirement could lead to better glycemic...
Bodenlenz, MEndahl, LDraeger, EJacobsen, L VPieber T, Wutte A, Plank J, et al. Comparison of pharmacody- namic and pharmacokinetic dose-response profiles between insulin detemir and NPH insulin in subjects with type 2 diabe- tes. American Diabetes Association. 64th Scien...