(2011) Nox2 and Nox4 mediate tumour necrosis factor-␣-induced ventricular remodelling in mice. J. Cell. Mol. Med. 15, 2601-2613Moe KT, Yin NO, Naylynn TM, Khairunnisa K, Wutyi MA, Gu Y, Atan MS, Wong MC, Koh TH, Wong P (2011) Nox2 and Nox4 mediate tumour necrosis ...
同时,NOX2/4水平减低。以上结果表明曲美他嗪可能通过下调肝组织NOX2/4表达,减轻氧化应激损伤,改善D-Galn/LPS诱导的小鼠急性肝衰竭。本研究以盐酸曲美他嗪为干预药物,从NOX2/4介导的氧化应激方向探究了抗氧化剂对ALF的保护作用,进一步提供了对ALF发病机制的深入了解,期望对ALF的抗氧化治疗提供新的思路。本研究未在...
Here we compared the effects of silencing the two NADPH oxidase (Nox) isoforms (Nox2, Nox4) found in the SFO on aortic and renal T cell activation during Ang II HTN. We targeted the SFO of C57Bl/6 mice with adenoviruses encoding siRNAs directed selectively against Nox2 and Nox4 (Adsi...
【摘要】目的 探讨烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶家族的主要成员NADPH 氧化酶2 (Nox2) 和Nox4 在小鼠肠炎模型结肠组织中的表达及意义.方法 选用6 ～ 8周龄的129S /SV 雄性小鼠建立结肠炎模型,将其随机分为对照组、1. 5%葡聚糖硫酸钠(DSS) 组和3. 0% DSS 组,对照组自由饮水,1. 5% DSS 组和...
Moreover, Nox2 or Nox4 knockdown or overexpression of S36 phosphorylation-defective mutant p66Shc(S36A) inhibits VEGF-induced mtROS, VEGFR2-pY, EC migration, and proliferation. In summary, Nox4-derived H 2 O 2 in part activates Nox2 to increase mtROS via pSer36-p66Shc, thereby enhancing...
摘要 Objective To observe the effect of Yixin Jiedu Formula drug serum on NADPH oxidase activity in H9 c2 myocardial cells with overexpressed Nox2 and Nox4 subunits, and reveal whether it could influence the regulation and control process of corresponding...
nox4下游蛋白 Nox4蛋白在细胞内发挥的作用是多样的。它参与了细胞内的氧化还原平衡调节。通过产生超氧阴离子,Nox4可以调节细胞内的氧化还原状态,影响细胞的生理功能。Nox4蛋白还参与了细胞的信号转导途径。Nox4蛋白可以与其他信号分子相互作用,调节细胞内的信号传递,影响细胞的生长、分化和凋亡等过程。 此外,Nox4...
We determined the effect of Hcy on caspase-3 activity, annexin V positivity, intracellular NOX1, NOX2, NOX4, and p47(phox) expression and localization, nuclear nitrotyrosine accumulation, and mitochondrial membrane potential (Delta I (m)). Hcy induced caspase-3 activity and apoptosis; this ...
nox4基因属于NADPH氧化酶家族,编码一种特定的蛋白质。该蛋白质是细胞膜上的一种酶,主要负责将氧气和NADPH还原辅酶连接在一起,形成一种特定的酶复合物,进而在细胞中催化氧化反应。这个过程产生的反应产物是活性氧,它在一些生理过程中起着重要的调节作用。 nox4基因在人体中的表达受到多种因素的调控。研究发现,一些信...
人NADPH氧化酶2(NOX2)elisa试剂盒 货号:SPS-10739 英文代号:NOX2 elisa试剂盒 自备物品 1.酶标仪(450nm) 2.高精度加样器及枪头:0.5-10uL、2-20uL、20-200uL、200-1000uL 3.37℃恒温箱 ELISA方法被广泛应用于各种抗原和抗体测定。但ELISA测定中影响因素较多,而且其操作中有一定的技术要求,下面盘点ELISA测定...