Os módulos são os seguintes: Completeum desses projetos de desafiopara ganhar um certificado digital no Microsoft Learnhoje! Prepare-se para a Imagine Cup 2024! Complete estes módulos para transformar suas ideias brilhantes em projetos de Startup e prepare-se para...
(Ala) (Fig.1f); and (3) introducing overall helix-destabilizing mutations44outside of the hydrophobic interface (Fig.1g). This gave the redesigns HERD-2.1–GFP through 2.4. The resulting constructs improved solubility while retaining protein condensation in cells (Fig.2a,band Supplementary Figs.7...
Fig. 1: Characterization of brighter and chromophore-specific mFAPs. aComputational model of de novo designed β-barrel variant mFAP2b showing protein backbone(cartoon)and bound DFHBI chromophore(sticks).b,cChemical structures of DFHBI and DFHBI-1T, respectively.d,eIn vitro titration ofdDFHBI oreDFH...
For each window the percentage GC content and the mean coverage of the Illumina and PacBio datasets was plotted using RStudio 2.13.1 and a Pearson correlation coefficient was computed for both datasets against percentage GC content using custom scripts (Additional file 1). Calculation of errors ...
(DS), because individuals with DS carry an extra copy of DYRK1A15,16,17. Decreased DYRK1A expression or activity is also pathogenic. For example, mice hemizygous forDYRK1Ahave substantial phenotypic defects, including smaller body size, microcephaly, reduced numbers of neurons, abnormal motor funct...