There are a number of limitations in our study. Firstly, as retrospective study, bias and confounders that are not identified cannot be addressed, and patients at the highest risk may be deemed too sick for maximal intervention and may be denied ICU treatment. Prediction of mortality was made ...
The purpose of this study is to explore whether CREB5 is involved in cisplatin resistance and its underlying molecular mechanism. In the study, we found that CREB5 regulated mitochondrial apoptosis through transcriptional activation of TOP1MT and participated in HNSCC cisplatin resistance. This newly ...
To study the performance of our counting algorithm, the average of operator counts was compared to the resulting predictions by RGCode. Firstly, we evaluated the correlation between both counting methods, using the Intraclass Correlation Coefficient (ICC) as a metric. The trained model showed an ex...
found that the TET value of FFKC group (47.3 ± 3.8 μm) was significantly lower than the control group (48.5 ± 2.9 μm) [34], but there was no significant difference between CET. The TET of FFKC group in the current study, however, was significantly thicker when ...
The purpose of the present study was to establish a new human osteosarcoma spontaneous metastasis model using orthotopic transplantation of histologically intact tumor tissue into the tibia of nude mice. Intact tumor pieces, obtained from the 32nd serial passage of subcutaneously growing human ...
This study has demonstrated that microbial treatment is a very competitive approach for the cleaner production of diosgenin when an ideal strain and process are utilized. The novel process involving a prior LSEP has a dual aim: not only for better contact between the microorganisms and the substrat...
Fig. 5. Effects of M-WS (Adaptra PM) on gene expression in human T98G neuroglia cells, which support the predicted inhibition of glucagon levels. Discussion The results of this study suggest that adaptogens exert a polyvalent biological activity and provoke multiple effects at the transcriptional...
The lower percentages observed across our study coincides with previously reported ethnic disparities [11, 12], as well as the increased presence of this fusion event reported for lower-grade tumours [37]. Previously attributed to an interstitial deletion or an insertional chromosomal rearrangements [...
This is the first large scale virtual prospective study describing the association between passively collected PGHD and constipation symptoms and severity at a day-to-day granularity level. Constipation status, irregular or constipated, was associated with a number of activity metrics in steps and ...
Organosulfates and sulfamates contain polar functional groups that are important for the study of molecular interactions in the life sciences, such as: neurodegeneration1; plant biology2; neural stem cells3; heparan binding4; and viral infection5. Recent total syntheses including 11-saxitoxinethanoic ac...