Spatial multi-omic studies have emerged as a promising approach to comprehensively analyze cells in tissues, enabling the joint analysis of multiple data modalities like transcriptome, epigenome, proteome, and metabolome in parallel or even the same tissue section. This review focuses on the recent ad...
These therapeutic modalities could also be useful to reveal the fundamental pathways of SARS-CoV-2 replication. There is also interest in testing whether immunotherapy or biological therapies, such as convalescent plasma and hyperimmune globulin, containing antibodies isolated from blood donated by people...
To date, 22 REVIEW DNA Nucleus mRNA Cytoplasm ASO mRNA ASO siRNA Protein Aptamer, small molecule Protein Ligand Ab, aptamer, small molecule Figure 1. Different therapeutic modalities intervene in different parts of the cell. Antibody (Ab) therapeutics intervene on extracellular proteins, by binding ...
Furthermore, the forestomach autofluorescence was not observed with other imaging modalities, i.e. IVIS imaging (Fig. S2) and confocal microscopy (Fig. S3). Importantly, only lesions in the SCJ were used for analysis and the forestomach area was excluded from quantification. Confocal microscopy ...
Nucleotide excision repair is a multigene-regulated DNA damage repair pathway that contributes to drug resistance in tumor cells [76]. Excision repair cross-complementation group 1 (ERCC1) and xeroderma pigmentosum group B (XPB) as two key genes in the Nucleotide excision repair pathway were signif...
Analysis of cell viability and cell adhesion of hydrogel samples: (a) intracellular cell adhesion of prepared hydrogel groups (CS-AT, CS-AT@OHA (3 %) and CS-AT@OHA (6 %)) by cell counting number per area; (b) proliferation ability of the hydrogel samples by quantification of DNA conten...
Image analysis methods for radiology data are more mature than for pathology, and are able to extract meaningful features from MR, PET, CT, and other medical imaging modalities. The global perspective of tumor provided by medical imaging is complementary to the tissue and molecular scale measure-...
Most of the modalities used in the medical imaging are in grayscale, so the size of the key for the encryption is chosen as 8-bit. For better encryption, pixels should undergo diffusion and confusion process. In our scheme, diffusion in the pixel bits is attained by means of the WSAA ...
effector cell cytotoxicity and survival. Still, this single adoptive immunotherapy strategy clearly has the potential to improve. From the current perspective, a single therapy has obvious advantages and disadvantages, resulting in clinical limitations. Tumor immunotherapy with many modalities is increasingly...
Of course, this multidisciplinary, translational approach is not restricted to ASD, but will further enhance our knowledge of many other complex disorders, thus allowing for the development of a broad range of novel therapeutic modalities with the hope of improved survival and quality of life for ...