83, ZMPSTE24 was reported as a virus-specific effector that restricts multiple RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia. ZMPSTE24 can combine with the interferon-induced transmembrane protein (IFITM) family, which eventually ...
Our recent research found that several natural products, including one new sesquiterpenoid with an antiviral activity against H5N1 influenza A virus, were produced in mono-culture of basidiomycete Phellinus ignarius but at low yield12. Zheng et al. demonstrated that co-cultivation of the same genera...
Viruses, such as influenza virus and CoVs, containing a furin-like cleavage site, which is cleaved by different cellular proteases including furin, have high pathogenicity and exert extensive cell tropism (Sun et al., 2010; Kido et al., 2012; Coutard et al., 2020). Bat CoV CD35 shares...
regional hospitals in Hong Kong during a five-year period (January 2010 to December 2014), and were tested negative for influenza A and B viruses, parainfluenza viruses types 1, 2 and 3, respiratory syncytial virus, adeno- virus, human metapneumovirus, human coronaviruses and human bocavirus2...
Interactions of p53/Arf and IFNβ pathways have been shown to play a role in controlling virus infection including through the induction of cell death.11,12 Here we have shown that the presence of the adenoviral vector and the activation of the p53/Arf and IFNβ pathways are critical for ...
SAW sensor for Influenza A virus detection enabled with efficient surface functionalization. Sens. Actuators B Chem. 2015, 209, 78–84. [CrossRef] 2. Dixon, B.; Kalinin, V.; Beckley, J.; Lohr, R. A second generation in-car tire pressure monitoring system based on wireless passive SAW ...
Dengue virus belongs to the Flavivirus genus, from the Flaviviridae family, and circulate as four major serotypes which do not induce long-term cross-protection in secondary infections [3]. The development of effective vaccines against dengue virus is technically challenging as it must induce a ...
Based on transcriptional signatures, this research uncovered a pathological role for neutrophils in the lungs of mice infected with lethal but not sub-lethal strains of influenza A virus (IAV) [31]. This guided therapeutic interventions, since attenuation (but not ablation) of neutrophils during ...
The average number of infections that can spread from a single infected individual in a fully susceptible population is measured by R0 [42]. R0 was found to be 2.7 for SARS from studies conducted on prior outbreaks and 2.4 for pandemic H1N1 influenza in 2009 [43,44]. Another study ...
Furthermore, the pathogenicity of rescued Re1966 was evaluated in specific-pathogen-free (SPF) chickens in comparison with the parental virus to identify the natural deletion, which is frequently present in highly virulent strains, as either a virulence-related factor or a non-essential replication...