作者: 美国新药获批。 US FDA Novel Drug Approvals for 2024. 美国新药获批。🔗: 网页链接
John JenkinsOffice of New Drugs in FDA’s Center for Drug Evaluation and Research中国药学(英文版)Jenkins, J. A Review of CDER's Novel Drug Approvals for 2016. https://blogs.fda.gov/fdavoice/index.php/2017/01/a-review-of- cders-novel-drug-approvals-for-2016/ (2017)....
The new functionality poses additional challenges, particularly in terms of stability (proteins and peptides), requirements for intracellular delivery (nucleic acids), and viability and expansion (living cells). To address these challenges, drug delivery strategies must evolve continuously [51]. For all...
For a successful regulation of the differentiation process, sustained release is needed, and this is usually achieved by encapsulating the active compounds within predefined drug delivery vehicles. Furthermore, the presence of such carriers makes it possible not only to inhibit their burst release and ...
a unique similarity matrix during three steps, and then, uses the constructed matrix to train a convolutional neural network (CNN). The model is used to suggest a suitable drug for a target disease. Relying on the results of conducted experiments, IDDI-DNN outperforms several state-of-the-art...
(Sigma-Aldrich, H4522). Drug dosing was as follows. A 10 mM stock solution of zosurabalpin compound in DMSO was used for preparing drug-containing medium and later for MIC measurements by serial dilutions in MHB medium with 2% DMSO in microtiter plates. Experimental evolution runs in ...
drug approvalevidence‐based medicinehealth care policyquality of lifeConcerns have been raised that regulatory programs to accelerate approval of cancer drugs in cancer may increase uncertainty about benefits and harms for survival and quality of life (QoL). We analyzed all pivotal clinical trials and...
and anti-inflammatory (Nrf-2 and HO-1) factors. Here, folic acid, a ligand for folate receptor which is overexpressed in IBD, was modified on the surface of the carrier to achieve colonic targeted delivery of the drug. In 2012, grape exosome-like NPs (GELNs) were proved by Zhang’s ...
Design, Setting, and Participants This cohort study identified novel drugs approved by the US Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research in 2020. The Drugs@FDA database was used to extract key characteristics of each drug’s pivotal trials. Drug approval packag...
The interaction of TKIs and BCRP was expected, as the IC50 or inhibitory constant (Ki) values for these TKIs, except vemurafenib, have been reported in literature or drug approval packages for regulatory agencies. Overall, 32 drugs involved in cancer therapies were strong BCRP inhibitors. The ...