442-CA best-in-class HSC-derived CAR-Monocyte product with a novel CAR costimulatory domain significantly improves CAR-M activity against solid tumorsdoi:10.1136/jitc-2023-SITC2023.0442-CBackground Myeloid cells, unlike other immune cells such as T cells or NK cells, are known residents in the ...
PF-06747143 is a novel and potentially first in class humanized IgG1 anti-CXCR4 antibody that recently entered into clinical studies (NCT02954653). Here, we show that it potently binds to CXCR4 and inhibits CXCL12-driven calcium flux. Moreover, it induces cell death in malignant CLL-B cells...
A study in mice demonstrated that the inhibition of MHC class II-induced B cells is unresponsive to initiating TH2 cells but confirmed their role in TH1 and TH17 responses [109]. In addition, B cells can be involved in airway inflammation and AHR induction in the absence of T cells [110...
Carboxy-terminus of Hsc70 interacting protein (CHIP) CHIP (carboxy-terminus of Hsc70 interacting protein) was first discovered as a chaperone-associated ubiquitin ligase39. The CHIP protein has a TPR domain at its N-terminus, through which it interacts with the molecular chaperones Hsc70, Hsp70 ...
This suggests that the HSC abnormalities in the Ikaros DN−/− mice result from the interference of Ikaros DN with another factor(s). We therefore sought to identify new Ikaros-related-interacting factors in the HSC population. This led to the identification of Helios, a novel member of ...
are the most abundant class of secondary metabolites with diverse functions in microbial, plant, and animal metabolism1. The building block of isoprenoid derivative compounds is isopentenyl diphosphate (IPP), which is synthesized via two non-homologous pathways: the mevalonate pathway and the 1-deoxy...
To confirm the effect of HS-173 on HSC proliferation, the level of BrdU incorporation was measured. As shown in Figure 1B, the proliferation of HSCs was significantly inhibited by HS-173 treatment. The activation of HSCs is a central pathophysiological mechanism underlying liver fibrosis, and a...
We therefore investigated whether pollen tube-secreted proteins possess class I or class II TMHs. Using TMHMM v2.0 algorithms, our analysis revealed no reliable prediction for the presence of TMHs in both conventionally (average of 11.03 amino acids in TMHs) and unconventionally secreted proteins (...
On the other hand, MHC Class II molecules are composed of a 34-kDa α-chain that is noncovalently associated with a 28-kDa β-chain (Germain, 1994). Class II molecules present peptides of 12–25 amino acids, with a groove-contacting region in the middle and side chains of several ...
8. Pinyol R, Sia D, Llovet JM, Immune exclusion-Wnt/CTNNB1 class predicts resistance to immunotherapies in HCC: Clin Cancer Res, 2019; 25(7); 2021-23 9. de Galarreta MR, Bresnahan E, Molina-Sánchez P, β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy ...