It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery. 产品信息 30540-1-AP targets NOTCH3 in WB, IP, ELISA applications and shows reactivity with Human, mouse samples. Tested Applications...
NOTCH3 geneIntronic deletionSplicing alterationCADASIL is the most prominent inherited form of vascular dementia. The main clinical features include migraine with aura, stroke, mood disturbances, and cognitive decline, with a mid-life (30s-60s) adult onset. Genetic testing is the gold standard for ...
The inclusion criteria were: (1) age ≥ 50 years old; (2) those who can cooperate with head MRI examination; (3) those who understand the study and agree to retain blood samples for SNP testing. Exclusion criteria were: (1) previous neurological diseases such as cerebrovascular disease, ...
不久前, 以色列生物技术公司Ayala Pharmaceuticals完成3000万美元B轮融资以用于三阴性乳腺癌(TNBC)药物AL101的临床试验。 Ayala Pharmaceuticals' pan-Notch, gamma secretase inhibitor AL101 showed promise in preclinical testing in triple-negative breast cancer. (National Cancer Institute) AL101, Bristol-Myers Sq...
In addition to utilizing genetic testing for the NOTCH3 gene for CADASIL diagnosis, we often perform histopathological analyses such as immunostaining to detect vascular Notch3 ECD aggregates and electron microscopic analyses to detect vascular GOM deposits [3,4]. However, these histopathological ...
This finding was the basis for developing the ‘NOTCH3 score’, a quantitative measure for the NOTCH3 accumulation load. This score proved to be a robust and sensitive method to assess the progression of NOTCH3 accumulation, and a feasible biomarker for pre-clinical therapeutic testing. ...
et al. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J. Clin. Invest. 120, 433–445 (2010). CAS PubMed PubMed Central Google Scholar Li, X. et al. Notch3 signaling promotes the ...
The specific methods of other behavioural testing, such as open filed test, novel object recognition (NOR), Y maze test, social interaction test (SIT), elevated plus maze (EPM), tail suspension test (TST) and forced swimming test (FST), were seen in the supplemental methods. Immunofluorescenc...
TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by 纬-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical ...
Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors. While cytoreductive surgery followed by platinum based chemotherapy are initially eff