Jack Gorski, Pierre Rollini & Bernard Mach 66 Accesses 9 Altmetric Explore all metrics Abstract The organization and sequence of the HLA-DR β chain genes are compared in the two supertypic groups, DRw52 and DRw53, which together account for more than 80% of HLA-DR alleles. From the ...
RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications. Haematologica. 2016;101:941–50. CAS PubMed PubMed Central Google Scholar Li Y, Buijs-Gladdines JGCAM, Canté-Barrett K, Stubbs AP, Vroegindeweij EM, Smits ...
Bernard Peissel, Jacopo Azzollini, Daniela Zaffaroni and Lidia Pezzani of the Fondazione IRCCS Istituto Nazionale dei Tumori (INT); Bernardo Bonanni, and Irene Feroce of the Istituto Europeo di Oncologia (IEO) and the personnel of the Cogentech Cancer Genetic Test Laboratory; MTLGEBCS: We would...
With its small, scaly body, pointy tail, and clawed feet, the tuatara seems to tick all the boxes to be a lizard – yet it isn’t. This ancient reptile is the sole survivor of its own evolutionary branch on the tree of life, the Sphenodontia. Until now, bi...
Recently, the advent of therapies targeting genomic alterations has improved the care of patients with certain types of cancer. While molecular targets wer
The correctness of this insertion was verified by DNA sequencing (data not shown). The KI allele encodes a transcript 42 nucleotides longer than WT IL-15Rα mRNA due to this insert in exon 6 (Figure 2D); RT-PCR of the KI allele confirmed its larger size than a WT IL-15 cDNA (Figure...
In this respect, the rareHOXB13p.G84E germline mutation (i.e. NM_006361.6:c.251 G > A; NP_006352.2:p.(G84E); rs138213197:C > T) was found to be associated with an increased risk to develop prostate cancer by linkage analysis and candidate gene sequencing of 200 genes ...
Bernard Peissel, Jacopo Azzollini, Daniela Zaffaroni and Lidia Pezzani of the Fondazione IRCCS Istituto Nazionale dei Tumori (INT); Bernardo Bonanni, and Irene Feroce of the Istituto Europeo di Oncologia (IEO) and the personnel of the Cogentech Cancer Genetic Test Laboratory; MTLGEBCS: We would...
Positive test results were confirmed through a commercial laboratory; negative test results reflect the research test which included common mutations in the Hispanic population, rather than full sequencing. Since the end of our study, some of the patients who tested negative on the “Hispanic panel”...
determined by deep sequencing. We propose that superinfection exclusion, if it occurs at all, is a consequence of a cross-reactive RNAi response to the viruses involved, explaining the lack of dominance of one virus type over another. A better understanding of the consequences of dual- and ...