H. Slater : Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation. Psychopharmacologia (Berl.) 4 , 114–125 (1963).Rathbun, R. C. , and I. H. Slater : Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activatiol. ...
widely used tricyclic antidepressant amitriptyline (AT) and its major metabolite nortriptyline (NT) has been developed employing 3H-AT as the radioligand and a rabbit antiserum to a bovine serum albumin conjugate of N-succinyl-nortriptyline... R Lucek,R Dixon - 《Research Communications in Chemical...
Nortriptyline is a secondary amine dibenzocycloheptene TCA as well as the major metabolite of amitriptyline. Similar to desipramine, nortriptyline appears in mother's milk and is metabolized by CYP2D6 to the primary amine and by ring hydroxylation to its E-10-hydroxy metabolite. Approximately one...
Nortriptyline is a secondary amine dibenzocycloheptene TCA as well as the major metabolite of amitriptyline. Similar to desipramine, nortriptyline appears in mother's milk and is metabolized by CYP2D6 to the primary amine and by ring hydroxylation to its E-10-hydroxy metabolite. Approximately one...
Four of the drugs were of the tricyclic type (amitriptyline/nortriptyline and melitraced litracen), t... A.,Jørgensen,V.,... - 《Acta Pharmacologica Et Toxicologica》 被引量: 5发表: 2009年 Diazepina derivatives for the treatment of depression and Pharmaceutical compositions containing same ...
Six healthy volunteers were given single doses of amitriptyline (AT) and of nortriptyline (NT) separated by at least 10 days. Plasma concentrations of both compounds were measured at intervals for 48 or 72 h. the total areas under the concentration-time curves for the ingested drug were ...
amitriptyline, desipramine, nortriptyline, and a number of other compounds. These drugs relieve symptoms in a high proportion (more than 70 percent) of depressed patients. As with the MAOIs, the antidepressant action of tricyclic drugs may not become apparent until two to four weeks after treatm...
Amitriptyline was introduced by Merck, Sharp and Dohme in 1961 and is widely used in the treatment of depression. Its value is not established, and it is not included in the BP or BPC. The drug is now available in 10 and 25 mg tablets from three manufacturers: Laroxyl (Roche), Saro...
AmitriptylineNortriptylineImipramineAlthough it is long known that the tricyclic antidepressants amitriptyline, nortriptyline and imipramine inhibit the noradrenaline transporter and α1-adrenoceptors with similar affinities, which may lead to self-cancelling actions, the selectivity of these drugs for α1-...
Arce R, Garcia C, Oyola R, Piñero L, Nieves I, et al. (2003) Photophysical and photochemical properties of amitriptyline and notriptyline hydrochloride: a 266 nm nanosecond laser flash and theoretical study . J Photochem Photobiol A: Chem 154 245–257...