In partial sciatic nerve ligation (PSNL) mice, the interaction of gabapentin with nortriptyline was evaluated by the hot plate assay using isobolographic analysis.Gabapentin (3-100 mg/kg, i.p.) or nortriptyline (1-30 mg/kg, i.p.) induced dose-dependent antinociception, with an ED50 of ...
Moreover, letdown effects of deep depression and physical exhaustion may occur after only a single dose of moderate strength wears off. With repeated use, tolerance develops, so that a user needs to take larger doses, but the accompanying dependence is not strong enough to be termed a ...