正常化富集评分(Normalized Enrichment Score, NES)是一种用于衡量基因集与生物过程之间关联程度的指标,广泛应用于生物信息学领域。在研究基因功能富集和生物通路的过程中,NES 能够为我们提供关于基因集与生物过程之间关系的有力信息。 ES 的计算方法较为复杂,涉及到的参数较多。首先,需要根据基因集与生物过程之间的关联...
The top enriched KEGG pathways for low risk genetic variants ranked by normalized enrichment score (NES).Paola, NicolettiMukesh, BansalCeline, LefebvrePaolo, GuarnieriYufeng, ShenItsik, Pe’erAndrea, CalifanoAris, Floratos
Suitable techniques comprise centrifugation, extraction, fractioning, ultrafiltration, protein precipitation followed by filtration and purification and/or enrichment of compounds. Moreover, other pre-treatments are carried out in order to provide the compounds in a form or concentration suitable for ...
We next investigated the efficiency of the library construction protocol with regard to the enrichment in full-length clones. The comparison with the results for the libraries not enriched in full-length clones clearly indicates that full-length libraries described here produced a considerably higher pe...
For each protein–ligand pair, we employ DiffDock to sample multiple poses, followed by utilizing the NMDN score to select the optimal binding pose, and estimating the binding affinity using scoring functions. Our protocol achieves an average enrichment factor of 4.96 on the LIT-PCBA data set,...
To address this problem, this paper presents a preference ranking organization method for enrichment of evaluations (PROMETHEE) based on the redefined PLTS and novel score function to solve MADM problems under a PLTS environment. First, an asymmetric normalized PLTS based on prospect theory (ANPLT...