In a community-based registry of HF patients (the COHERE [Carvedilol Heart Failure Registry] study), the benefit of carvedilol therapy was less, with a 6% mortality reduction for patients with an LVEF >40% (41). In this registry, the mortality reduction did not differ across the range of ...
Viability, fertility, and a range of histological, hematological, serum--chemical, and immunological parameters were not abnormal in mdr1a/1b (-/-) mice. The high level of mdr1b P-gp normally present in the pregnant uterus did not protect fetuses from a drug (digoxin) in the bloodstream ...
For example, a reference range for glucose by age-group and sex should be determined in a corresponding population of people who do not have comorbidities related to diabetes. A main goal in determining reference ranges is to identify laboratory test values that distinguish between patients with ...
The 95% REM range can be thought of as analogous to the ‘95% rule’ for normal distributions, enclosing the middle 95% of the distribution, but expressed on the effect rather than linear predictor scale. We use square brackets [⋅] to denote REM ranges and round brackets (⋅) to ...
Mdr1a/1b (-/-) mice lack both genes encoding for P-gp and these mice seem physiologically normal. The penetration of [3H]digoxin (a P-gp substrate) was higher in brain, ovary and adrenal gland. In the lung tissue of these (-/-) mice [39], the level of [3H]digoxin was rather ...
(e.g., osteoarthritis); impaired gait, balance or walking ability stemming from cerebrovascular disease, degenerative disorders of the central nervous system, or peripheral vascular disease; fatigue or weakness due to a range of systemic illnesses or increasing frailty; and poor exercise conditioning,...
Mdr1a/1b (-/-) mice lack both genes encoding for P-gp and these mice seem physiologically normal. The penetration of [3H]digoxin (a P-gp substrate) was higher in brain, ovary and adrenal gland. In the lung tissue of these (-/-) mice [39], the level of [3H]digoxin was rather ...
The ATP-binding cassette (ABC) transporters P-glycoprotein (MDR1/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) play a crucial role in the translocation of a broad range of drugs; data about their expression and activity in...