Ivabradine did not prolong QTc or modify conductivity and refractoriness of the atrium, AV node, His-Purkinje system and ventricles, or repolarisation duration. These results confirm the action of ivabradine as a specific heart rate-lowering agent....
No arrhythmic phenotypes were observed in available female carriers, but 3/4 (75%) showed minor ECG abnormalities such as AV block (PR < 200 ms) and/or prolonged QTc interval (>470 ms, range 478–488 ms). Moreover, a total of seven individuals from a single kindred carried the p....