The major limitations of this study are related to the assessment of pathological findings: patient population was very heterogeneous without inclusion criteria based on clinical indication, Gleason score or PSA levels. The exact effect of the irradiation or hormone therapy on the normal expression of ...
Keywords: prostate cancer; manganese porphyrin; radiation; ROS; lipid oxidation 1. Introduction One of the most common treatments for prostate cancer is radiation therapy. Increased production of reactive oxygen species (ROS) is reported during and after radiation therapy [1]. Radiation-mediated ROS,...
The fact that Wnt signaling may augment AR signaling has implications for therapy due to the frequent recurrence of prostate cancer after androgen Cancers 2011, 3 2062 deprivation therapy. If Wnt inhibition can be confined in a targeted manner to PCSCs, it may be possible to treat castration-...
Prostate-specific antigen (PSA) levels can be used to detect prostate cancer, and the Gleason score is used to determine the severity [7,109]. The Gleason score is a measurement of the tumor’s differentiation, with poorly differentiated tumors having a higher score than well-differentiated ...