Fresh biopsies from one patient with MUTYH-associated familial adenomatous polyposis were obtained by colonoscopy. Tissues (approximately 0.5 × 0.5 × 0.5 cm3in size) were cut from four polyps. Matched blood and buccal mucosa tissue from the same patient were also collected. All t...
Introduction Colonoscopy and flexible sigmoidscopy are the primary tools for diagnosis of CRC, although they have false negative rates of 2–6%. The aim of this study was to estimate how frequently lower GI endoscopy might have failed to detect cancer within 36 months preceding a confirmed ...
We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of colorectal polyp(s)/cancer, and controls as having no history of colorectal neoplasia. Molecular analyses were performed for: ...
Regression analysis was carried out in DESeq2 [31], while accounting for age at the time of colonoscopy and biological sex. This led to the identification of 2635 significant DEGs (FDR < 0.05), 59.66% of which displayed increased expression in colon organoids of FAP versus healthy subjects ...