Conclusion: Our finding of significantly higher VWF RNA expression in the PAM50 normal (non-basal-like) breast cancer subtype suggests that VWF protein measurement might complement or corroborate PAM50 results. VWF and PAM50 results both suggesting a low risk of recurrence might make the decision ...
However, some investigators treat the so-called "unclassified" Ihc subgroup (negative for all the five markers) as the normal-like subtype. We have to understand that the normal-like subtype is absolutely different from the immunohistochemically "ER–, PR–, HER2–, CK5/6–, and HER1–" ...
We hypothesized that cells present in normal tissue that bear cancer stem cell markers may represent a cancer cell of origin or a microenvironment primed for tumor development, and that their presence may correlate with the clinically defined subtypes of
Breast Cancer Research volume 26, Article number: 6 (2024) Cite this article 1703 Accesses Metrics details Abstract Background Reports of dual carriers of pathogenic BRCA1 variants in trans are extremely rare, and so far, most individuals have been associated with a Fanconi Anemia-like phenotype....
Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients. Breast Cancer Res. 2017;19(1):8. doi:10.1186/s13058-016-0791-4PubMedGoogle ScholarCrossref 14. Iyengar NM, Gucalp A, Dannenberg AJ, Hudis CA. ...
(B) The Metabric breast cancer patient cohort (n = 1,980 patients) (Curtis et al., 2012) was interrogated with the AXL MaSC gene signature (AXL-stem, Table S1) to access the distribution correlated with the degree of basal-like gene expression in breast cancer (ρ = 0.181, p = 5.5 ...
breast tissue from this case exhibited normal histology, but the organoids in culture were predominantly composed of luminal progenitor cells. Interestingly, the luminal progenitor cells had abnormal characteristics, such as high expression of ERα, distinct from the luminal progenitor subtype identified ...
Cancer cells harbor a large number of mutations on diverse genes with a wide range of occurrence frequencies1. Mutations on “driver” genes alter important cellular processes – such as the “hallmarks” like cell proliferation, apoptosis and angiogenesis – and thus drive oncological phenotypes such...
Here we demonstrate through analysis of human survival data that expression of LINC00968 in primary tumors of the breast is correlated with overall survival in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed non-coding ...
We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0...