LDL-C, even at levels currently considered normal, is independently associated with the presence and extent of early systemic atherosclerosis in the absence of major CVRFs. These findings support more effective LDL-C lowering for primordial prevention, even in individuals conventionally considered at ...
Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to N... OBJECTIVE: The Treating to New Targets study showed that intensive lipid-lowering therapy with atorvastatin 80 mg/day provides significant clinical...
You need some LDL cholesterol protein to carry cholesterol to your body’s cells so that they can function properly. But it’s pretty rare to have LDL cholesterol levels that are too low. If you have too much LDL, it can build up as plaque in your blood vessels, increasing your chance ...
Low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol, is the type that tends to deposit on the walls of the arteries. White blood cells combine with the LDL cholesterol, forming artery-narrowing plaque, which restricts blood flow. The optimal level of LDL cholestero...
Cholesterol is present in all body tissues and is a major component of LDL, brain, and nerve cells, cell membranes, and some gallbladder stones. Triglycerides constitute a major part of very-low-density lipoproteins and a small part of LDLs. Increased cholesterol levels, LDL levels, and trigly...
Moreover, basal insulin, total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and triglyceride levels in the overweight group were found to be significantly higher. However, there were no differences in triglyceride and total cholesterol in plasma between the normal...
AtherosclerosisRetterstol K, Svendsen M, Narverud I, Holven KB. Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study. Atherosclerosis. 2018; 279: 52-61....
Apterkmann NP, Cesar, TB (2013) Long-term orange juice consumption is associated with low LDL-cholesterol and apolipoprotein B in normal and moderately hypercholesterolemic subjects. Lipids in Health and Disease 12: 119.Aptekmann NP, Cesar TB. 2013. Long-term orange juice con- sumption is ...
First, as described above, LXRs contribute to maintaining cellular cholesterol homeostasis by controlling transcriptional programs involved in lipid homeostasis (Zelcer and Tontonoz, 2006). Macrophages take up oxidized-LDL, and its increased cellular concentration activates LXRs, which induce the efflux of...
The hypercholesterolemic diet increased plasma cholesterol (186%), particularly that associated with very low (VLDL) and low (LDL) density lipoproteins. In addition, the cholesterol/triglyceride ratio in the VLDL fraction rose significantly from 0.10 to 4.0. The hypertriglyceridemic diet raised ...