findings in black newborns (27), this latter case might be an a- thalassemia trait. A surprising finding was the detection of three different y chain variants (2.3%). Other recent studies have permitted identification of a large number of such variants. which may be more frequent than ...
These findings suggest that methylation of RUNX1 by PRMT1 on these sites is critical for proper peripheral T-cell maintenance. Download: Download high-res image (173KB) Download: Download full-size image Figure 1. Diagram of the RUNX1 protein and sites of regulation by the PRMT family. The...
4), 100,000 target cells were cocultured with 1G4, T1 or T3 TCR-transduced PBMCs for 5 days in T-cell medium at a 1/1 ratio in a round-bottom, 96-well plate in triplicate. To observe the presence or absence of proliferation for both CD4+ and CD8+, transduced cells were ...
Our findings provide evidence of the involvement of TGFβ1 signaling in the suppression of normal HSCs in AML hosts. Both excessive production and activation of TGFβ1 accounted for upregulation of TGFβ signaling in leukemic bone marrow. We reported for the first time that TGFβ1 directly init...
Our findings indicate that VLA-4 is a potential target gene of PLZF. However, in primary AMLs the control of PLZF on VLA-4 expression is lost. Altogether, we suggest that VLA-4 modulation by PLZF may represent an important step in the control of normal and leukemic cell mobilization....
Mesenchymal stem cells (MSC) represent a heterogeneous population exhibiting stem cell-like properties which are distributed almost ubiquitously among perivascular niches of various human tissues and organs. Organismal requirements such as tissue damage
Our findings demonstrate a strong link betweenTET2mutation status and CpG hypermethylation at sites associated with gene-regulatory function already at the pre-malignant state. We next asked to what extent methylation status was predictive ofTET2mutation status. To this end, we developed a DNA methyla...
Altogether, these findings strongly indicate that HGF/Met signalling is required for normal mitochondrial function and redox homeostasis in adult cardiomyocytes. 3.3. Met acts on p38 MAPK to increase antioxidant enzymes levels and counteracts TGF-β effect in cardiomyocytes We next aimed at uncovering ...
These and similar future findings are likely to have a major impact on the clinical management of cytogenetically normal AML not only in prognostication but also in selection of appropriate treatment, since many of the identified genetic alterations already constitute or will potentially become targets...
(Fig.5q, r). These findings raised the question of whether B cell-extrinsic proinflammatory cytokines resulting from constitutive STING activation in V154M mice could influence antibody production and secretion. Thus, we further exposed LPS-stimulated WT plasmablasts to high concentrations of IFNβ ...