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This study seeks to clarify whether IS exerts a potent modulating effect on the hepatictransport of pravastatin, which is a substrate of both organic aniontransporting peptides (OATPs) and multidrug resistance-associated protein (Mrp)2 in rats. When IS is administered intravenously to the normal ...
Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome. The metabolic syndrome (MS) is a constellation of coronary risk factors. Atherogenic dyslipidemia is an important factor in cardiovascular risk in these...
Indeed, it is difficult to estimate the local concentration within target tissues of a statin administered at a given dose (a reported correspondence is 80 mg per daily dose into ∼0.2 μM in patient serum [127,154], consistent with a border-line effect on lymphocyte rafts observed with ...
Arteries were incubated for 2 h with 1 μM pitavastatin or pravastatin; time-controls in parallel. U46619 dose–response curves were repeated or NO-donor SNP (1 nM–100 μM) or endothelium-dependent bradykinin (0.1–1000 nM/L) following U46619 pre-constriction. All data are mean ± SEM. ...