In fact, it is significant only for normal heparins whereas it is not for LMW heparins. A good relation was observed, also, between anti-activated factor X activity/antiglobal clotting activity (Xa/APTT) ratio of different heparins and the effect on platelet release....
METHODS AND RESULTS: We developed and tested a prototype of an automated heparin control system (AutoHep) in which a computer-based titration algorithm adjusted the heparin infusion to reach a target aPTT. In 1 study, 12 healthy male subjects received an intravenous infusion of heparin with ...
To confirm RagHemoA phenotype, the clotting time of mouse plasma was determined by activated partial thromboplastin time (aPTT) using a semiautomated coagulometer (BioMerieux, France). FVIII assays The concentration of human FVIII was determined in mouse plasma by an enzyme-linked immunosorbent assay...
Prolonged APTT is a more complex concern as it can be caused by heparin or hemophilia but we plan to look closer to this problem in the future. The limitation of the study is the fact that at the time of performed tracheostomy the primary cause and reason for admission to ICU had almost...
Heparin anticoagulant activity estimated by the APTT disappeared faster than heparin anticoagulant activity estimated by the anti-Xa activity in the first phase. As expected, higher anticoagulant levels with the anti-Xa assay than with the APTT were also found on continuous infusion in normals as ...
A multiple linear regression equation with hematocrit and baseline APtt as independent variables yielded a multiple correlation coefficient of 0.875 (p < 0.01). Thus, it may be possible to predict the APTT value produced by a given concentration of heparin in an individual subject from the subject...