All but one of the DS sera had SP-1 levels greater than the normal median. Using a cutoff of 2.8 multiples of the median (MoM), 15.2% of the DS pregnancies were detected with a false-positive rate of 4.3%. A combinational logistic regression analysis of maternal age and pregnancy ...
There is also a known association of markedly elevated AFP levels with congenital nephrosis. We identified a case with a successful pregnancy outcome where 80 MoM of AFP was noted during the second trimester screening. The risk factors identified were nulliparity and smoking. This level of AFP ...