High levels of either NOP10 mRNA or protein were associated with poor prognosis in NSCLC patients. Loss of NOP10 and subsequent reduction of H/ACA box snoRNAs and rRNA pseudouridylation inhibited lung cancer cell growth, colony formation, migration, and invasion. A focused CRISPR/Cas9 snoRNA ...
This renders the protein completely inactive in pseudouridylation22 (data not shown) while retaining its RNA binding abilities (see below). Subsequent to a 10 minute incubation of 10 nM [3H]tRNA in the presence of excess protein, the reaction mixture was filtered Table 1 | Kinetic parameters ...
Uniprot ID Q9NPE3 基因名全称 H/ACA ribonucleoprotein complex subunit 3|Nucleolar protein 10|Nucleolar protein family A member 3|snoRNP protein NOP10 推荐稀释比 Western blot (WB) 1:500～2000IHC 1:50～1:200相关搜索:NOP10抗体,NOP10单抗,Anti-NOP10 Antibody (Clone#27N61)首页...
Additionally, NOP10 protein is located both at the nuclear and nucleolar level, suggesting the dual role of NOP10 in our mPGGL. Regarding the role of NOP10 in telomere maintenance, our in vitro results showed that NOP10 on its own has not had a direct effect on the telomere length. ...
英文名称 Human Nucleolar protein 58(NOP58)ELISA Kit 储存条件 2-8℃冷藏 种属 人、Human 特色服务 免费代测 规格 48T/96T 产地 上海 性能优势 重复性好 检测方法 酶联免疫 保质期 6个月 货期 现货供应 样品类型 血清、血浆和其他生物体液。 可售卖地 全国 用途 仅供科研使用 型号 A10276...
TMEM1重组蛋白;高活性/Recombinant human TMEM1 protein 公司简介 湖北艾普蒂生物工程有限公司(简称:艾普蒂)由在国内科研试剂领域有着十几年从业经验的专业技术团队和企业管理团队组建而成,专门从事以抗体、蛋白、细胞、化学品为核心的试剂产品研发与销售。
Cbf5 is the H/ACA protein that catalyzes isomerization of uridine to pseudouridine in target RNAs. Mutations in human Cbf5 (dyskerin) lead to dyskeratosis congenita. Here, we describe the 2.1 A crystal structure of a specific complex of three archaeal H/ACA proteins, Cbf5, Nop10, and Gar...
The NOP receptor activity was evaluated by G-protein coupled inwardly rectifying potassium (GIRK) currents in rat vlPAG slices, and by inhibition of cAMP accumulation in HEK293 cells expressing NOP receptors or co-expressing NOP and MOP receptors. In vlPAG neurons, [Tyr10]N/OFQ(1-11), ...