Translation is pervasive outside of canonical coding regions, occurring in long noncoding RNAs, canonical untranslated regions and introns1"4, especially in ageing, neurodegeneration and cancer. Notably, the majority of tumour-specific antigens are results of noncoding translation. Although the ...
Translation is pervasive outside of canonical coding regions, occurring in long noncoding RNAs, canonical untranslated regions and introns1,2,3,4, especially in ageing4,5,6, neurodegeneration5,7 and cancer8,9,10. Notably, the majority of tumour-specific antigens are results of noncoding transl...
How cells suppress the translation of potentially toxic proteins from various noncoding sequences remains poorly understood. This review summarizes mechanisms for the mitigation of noncoding translation, including the BCL2-associated athanogene 6 (BAG6)-mediated proteasomal degradation pathway, which has ...
Noncoding translation mitigation Nature, 617 (2023), pp. 395-402, 10.1038/s41586-023-05946-4 Google Scholar This study showed a surprising pathway for limiting noncanonical translation from lncRNAs and mRNA UTRs. Ribosomes have been detected on a subset of lncRNAs, upstream open reading frames,...
The lncRNA XIST, among the earliest lncRNAs to be characterized, has been discovered to additionally assist in the advancement of AML Dox resistance [129]. XIST was discovered to function as a scaffold for miR-29a, resulting in the mitigation of the suppression of the oncogene MYC. By suppres...
Similarly, lysosomal inhibition showed no effect in a high-throughput analysis of ~12 000 human sequences [24], nor did autophagy-lysosomal genes show any significant effect in the genome-wide CRISPR screen that identified BAG6 as a master regulator of noncoding translation mitigation [24]. ...
In general, DI-RNAs have complex relationships with the helper virus (HV) regarding the competition for viral- and host factors, and mitigation of antiviral responses and/or disease symptoms in the host plant. D RNAs have also been reported in the tomato black ring virus (TBRV), one of ...