Targeting of G proteins to places such as the Golgi has resulted in identification of βγ signaling upstream of phospholipase C (PLC), Protein Kinase D (PKD), and phosphatidyl inositol 4 kinase IIIβ (PI4KIIIβ). Together activation of this pathway results in vesicle fission from the Golgi...
23. To identify which neuropeptide plays a key role in the cell non-autonomous regulation of mitochondrial stress signaling, we employed the CRISPR-Cas9 system and designed sgRNA sequences to specifically knock out all 103 reported neuropeptide genes inC. elegans(...
Additionally, protein interactions in signaling pathways are emerging as important therapeutic targets for cancer and other human diseases (reviewed in ref . 4 ). These and other similar pathways of protein interactions in specific tissues produce regional effects that cannot be investigated fully with ...
In the absence of any protein product, the hsrw transcripts are suggested to interact with the Ras 1 signaling cascade. The interaction of a non-translatable, developmentally produced as well as heat and other stress inducible RNA with the Ras signaling proteins and with the Hsp83 chaperone ...
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At present, although many small molecule inhibitors of the Wnt/β-catenin signaling pathway have been identified, none of the drugs has been approved for clinical use101. SAHPA1 and xStAx are two Axin-based stapled helical peptides that can bind to β-catenin, but in vivo, due to the ra...
is involved in many cellular processes, including protein degradation by the proteasome and autophagy, quality control of proteins [e.g., endoplasmic reticulum (ER)-associated degradation] and organelles, as well as mRNA translation, endocytosis, DNA damage response, and intracellular signaling. These...
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A. et al. Interplay of long non-coding RNAs and TGF/SMAD signaling in different cancers. Cell Mol. Biol. 64, 1–6 (2018). Article PubMed Google Scholar Xie, H. et al. Synthetic artificial ‘long non-coding RNAs’ targeting oncogenic microRNAs and transcriptional factors inhibit malignant...
Endogenous ligand-activated GPCR coupling with the G-protein begins a signaling cascade process (referred to as “signal transduction”). Under normal conditions, signal transduction ultimately results in cellular activation or cellular inhibition. It is thought that the IC-3 loop as well as the ...