Recurrence and clustering of somatic mutations (hotspots) in cancer genomes may indicate positive selection and involvement in tumorigenesis. MutSpot performs genome-wide inference of mutation hotspots in non-coding and regulatory DNA of cancer genomes. MutSpot performs feature selection across...
The somatic eQTL network is disrupted in 88% of tumors, suggesting widespread impact of noncoding mutations in cancer.doi:10.1038/s41588-018-0091-2Wei ZhangAna Bojorquez-GomezDaniel Ortiz VelezGuorong XuKyle S. SanchezJohn Paul ShenKevin Chen...
工具1:结果直接可用,输入输出都很明确 Predicting the functional impact of protein mutations: application to cancer genomics http://mutationassessor.org/r3/ 工具2: Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles https://zhanglab.ccmb.me...
Mutations within the functional, non-coding regions of the genome can alter gene expression, splicing, expression of non-coding transcripts, and the epigenetic state [33]. As of today, no studies have focused on the non-coding constraint regulatory elements of the GBM genome, and thus, the im...
"We know a lot of the mutations in breast cancercellshappen to be on noncoding regions of the genome," Prasanth said. "If these mutations are contributing to cancer, but are not coding for a protein, what are they doing?" First, the researchers analyzed RNA expression in cells of a ...
Genetic mutations linked to a disease often spell bad news. Mutations in over 25 genes, for example, are associated with amyotrophic lateral sclerosis, or ALS, and they all increase the risk of developing this incurable disorder. Now, a research team hea
Discriminating mutations arising during the evolution of mammals which were selectively neutral from those which were adaptive is an important challenge for the current genomic era. In the main, beneficial mutations in mammalian genomes appear to have been gene duplication, rapid sequence divergence, and...
LncRNAs in cancer chemoresistance As essential molecules on regulating tumor progression, lncRNAs have been considered as mediators involving in different mechanisms of chemoresistance, such as altering drug efflux, interfering DNA damage repair, triggering apoptosis, inducing mutations of drug targets, etc....
(A) Schematic of the SLNCR1 sequences expressed in (B), zoomed in on the region containing site-directed mutations within the AR-binding motif. (B) Matrigel invasion assays of A375 cells transfected with either an empty vector or a vector expressing the indicated SLNCR1 sequence. SLNCR1cons...
Recurrence and clustering of somatic mutations (hotspots) in cancer genomes may indicate positive selection and involvement in tumorigenesis. MutSpot performs genome-wide inference of mutation hotspots in non-coding and regulatory DNA of cancer genomes. MutSpot performs feature selection across hundreds ...