Non-canonical autophagy: an exception or an underestimated form of autophagy ? Autophagy 2008; 4 :1083-5; PMID:18849663; http://dx.doi.org/10.4161/auto.7068 [ Cross Ref ]Scarlatti F, Maffei R, Beau I, Ghidoni R, Codogno P. Non- canonical autophagy: an exception or an underestimated ...
Autophagy is a fundamental catabolic process that uses a unique post-translational modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). ATG8 lipidation also occurs during non-canonical autophagy, a parallel pathway involving conjugation of ATG8 to single membranes (CASM) at ...
Autophagy is induced by various cellular stresses, such as starvation, hypoxia and viral infection. Under stress conditions, cells use autophagy to maintain the cellular homeostasis for the optimal levels of intracellular macromolecules and ATP. Non-canonical pathways of autophagosomal degradation by bypass...
including the evolutionarily anti-viral autophagy pathway, for productive infections. Despite the emergence of double-membraned autophagosome-like vesicles during CVB3 infection, very little is known about the mechanism of autophagy initiation. In this study, we investigated the role of established...
AUTOPHAGYThe inflammasome is a cytosolic multiprotein platform that plays a key role in the inflammatory response, an essential innate immune response that protects the body from pathogens and cellular danger signals. Autophagy is a fundamental cellular mechanism that maintains homeostasis throu...
Autophagy-essential proteins are the molecular basis of protective or destructive autophagy machinery. However, little is known about the signaling mechanisms governing these proteins and the opposing consequences of autophagy in mammals. Here we report that a non-canonical MEK/ERK module, which is ...
it was originally described thatthese peptides can also originate from macroautophagy substrates. In recent years it hasbecome clear that in addition to this canonical function of the macroautophagy machineryduring MHC class II restricted antigen presentation at least parts of this machinery are alsous...
Huang, Ubiquitin-mediated regulation of autophagy. J. Biomed. Sci. 26, 80 (2019) Article PubMed PubMed Central Google Scholar X. Shan et al., Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis. Cell. Mol. Immunol. 19, 1263–1278 (2022) Article PubMed...
Direct and indirect effects of the pRb tumor suppressor on autophagy. Autophagy 7, 544–546 (2011). Article PubMed CAS Google Scholar Indovina, P., Pentimalli, F., Casini, N., Vocca, I. & Giordano, A. RB1 dual role in proliferation and apoptosis: cell fate control and implications ...
splicing factors on autophagy also largely depends on the stage of cancer. Thus, at the early stages of tumorigenesis, autophagy can suppress tumor development, while at later stages it can promote the survival of tumor cells and protect them from various therapeutic interventions [119]....