This response is potentiated by coinhibition of the lysine demethylase LSD1, leading to differentiation in most non-APL AML. Induction of differentiation was not correlated to a specific AML subtype, cytogenetic, or mutational status. Our study shows a previously uncharacterized role of GCN5 in ...
Correction: The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AMLAn amendment to this paper has been published and can be accessed via a link at the top of the paper.doi:10.1038/s41375-020-0706-3Melanie KahlAnnamaria Brioli...
Acute myeloid leukemia (AML)retinoic acid (RA)cell differentiationLynsrc family kinase (SFK) inhibitorbosutinibIn the present study, we determined the effects of the Src family kinase (SFK) inhibitor, Bosutinib, and the engineered loss of the Lyn SFK on all-trans retinoic acid-induced leukemic ...
These approaches are, in general, non-cross resistant and should be well tolerated particularly in elderly patients with AML. Clinical studies which include biologic end points for differentiation induction, histone acetylation and selective apoptosis are presently in development to evaluate these ...
Acute myeloid leukemia (AML)Non-acute promyelocytic leukemia (non-APL)Disseminated intravascular coagulation (DIC)Chinese DIC scoring system (CDSS)60-day mortalityAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy, and is one of the triggers of DIC, the latter is an essential ...
Effects of bone marrow stroma on atRA-induced differentiation of non-APL AML cells.doi:10.1371/journal.pone.0127790.g003S. MengA. SalvadorW. JonesJaceYu JianshiA. KaneMaureenJ. J. RichardG. GabrielPLOS ONE
CRBPI as well as CRABPI and II were expressed in all tested cell lines and in leukemic cells from all 18 AML-patients. CRABPII mRNA expression was more abundant than CRBPI and CRABPI in both the cell lines and the patient cells but the levels compared the house keeping gene was lower ...
Although AML-M3 (APL) and HLA-DR negative non-APL are characterized by negative HLA-DR antigen, they are different entities with similar morphology in some cases. The aim of this study is the precise, differential diagnosis of APL from HLA-DR negative non-APL by flow cytometry to narrow ...
60-day mortalitySerum albuminSerum albumin was significantly associated with 60-day mortality of primary AML, which has important clinical significance. Further investigation is warranted.doi:10.1186/s12885-022-10231-0Xiao, ZuomiaoDepartment of Clinical Laboratory, The Affiliated Ganzhou Hospital of ...
Although AML-M3 (APL) and HLA-DR negative non-APL are characterized by negative HLA-DR antigen, they are different entities with similar morphology in some cases. The aim of this study is the precise, differential diagnosis of APL from HLA-DR negative non-APL by flow cytometry to narrow ...