非酒精性脂肪性肝炎赛道研发的冰与火 非酒精性脂肪肝(Nonalcoholic Fatty Liver Disease,NAFLD)是指酒精和其它明确的损肝因素之外所致的肝细胞内脂肪过度沉积引发的代谢应激性肝脏损伤。非酒精性脂肪性肝炎(Nonalcoholic Steatohepatitis,NASH)是NAFLD进展而来的严重慢性肝脏疾病,流行病学数据显示,15%～25%的NAFLD患者最终...
Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer progression, but the underlying mechanisms remain unclear. In this study, we investigated the impact of NAFLD on breast cancer tumor growth and cell viability through the potential mediator, hepatic fibroblast growth ...
NAFLD是指除外酒精和其他明确的损肝因素所致的肝细胞内脂肪过度沉积为主要特征的临床病理综合征,与胰岛素抵抗和遗传易感性密切相关的获得性代谢应激性肝损伤。包括单纯性脂肪肝(SFL)、非酒精性脂肪性肝炎(NASH)及其相关肝硬化。非酒精性脂肪性肝病除可直接导致失代偿期肝硬化、肝细胞癌和移植肝复发外,还可影响其他慢性...
Liver metastasis is the major reason for most of colorectal cancer (CRC) related deaths. Accumulating evidence indicates that CRC patients with non-alcoholic fatty liver disease (NAFLD) are at a greater risk of developing liver metastasis. With the growing prevalence of NAFLD, a better understanding...
Non-alcoholic fatty liver disease (NAFLD) is associated with low level of physical activity: a population-based study BACKGROUND: High intensity exercise improves metabolic status and may potentially mobilise hepatic fat. AIM: To assess the level of physical activity (PA) ... L Gerber,M Otgon...
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in the Western world and is increasing owing to its close association with obesity and insulin resistance. NAFLD represents a spectrum of liver disease that, in a minority of patients, can lead to progressive...
NASH(non-alcoholic steatohepatitis),即非酒精性脂肪性肝炎,是由肝脏中脂肪堆积引起的肝脏疾病和炎症。根据流行病学数据,全球酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)发病率约25%,这些患者约有10-20%的可能进展为NASH,全球各地NASH发病率约为1.5%至6.5%,中国约为3.5%(即目前美国NASH患者人数约为...
Nonalcoholic fatty liverdisease is a major public health burden. Although many features of nonalcoholic fatty liver disease pathogenesis are known, the specific mechanisms and susceptibilities that determine an individual’s risk of developing nonalcoholic steatohepatitis versus isolated steatosis are...
非酒精性脂肪性肝病(nonalcoholicfattyliverdisease, NAFLD)是发达国家或地区最常见的肝脏疾病。脂肪肝是由 肝细胞内脂肪蓄积过多所致的肝脏疾病,当肝组织中脂类含量 超过肝湿重的10%～15%,或在组织学上超过50%的肝细胞 出现脂肪浸润,即可诊断为脂肪肝
OBJECTIVE: Nonalcoholic steatohepatitis (NASH) is a common but poorly understood liver disease. Our aim was to study a large group of patients referred for... IR Willner,B Waters,SR Patil,... - 《American Journal of Gastroenterology》 被引量: 1359发表: 2001年 Patients with elevated liver en...