Figure S31b illustrates the assembly lines generated from surugamide BGC by deleting A-domains appearing on zero, one, and two NRPS subunits, out of the four NRPS subunits encoded by the four ORFs appearing in this BGC. For example, for surugamide BGC with four ORFs (shown in yellow in ...
Our study investigated the effects of genetic and non-genetic factors on cognitive impairment. We approached the problem with two novel aspects compared with prior studies. First, we adopted the approach of stratifying individuals with a phenotype of exceptional longevity & normal cognition and contrast...
Many methods have been proposed recently for high-dimensional data representation to reduce the dimensionality of the data. Matrix Factorization (MF) as an efficient dimension-reduction method is increasingly used in a wide range of applications. However, these methods are often unable to handle data...
The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Reprints and permissions About this article Cite this article Wang, Z., Zhu, T., Ma, W. et al. Genome-wide ...
(Additional file9: Figure S4F). We then included genes whose non-zero mean levels across all cells were above 20.6 ncounts, corresponding to two copies per cell. Furthermore, we omitted genes that were detected in fewer than three single cells unless they were considered to be expressed by...
High-throughput transcriptome sequencing (RNA-seq) technology promises to discover novel protein-coding and non-coding transcripts, particularly the identification of long non-coding RNAs (lncRNAs) from de novo sequencing data. This requires tools that a
We propose a new microstructure model based on three non-exchanging compartments that explicitly includes the soma contribution to the intra-cellular signal as a pool of water diffusing in restricted geometries of non-zero size, i.e. not a dot-compartment (Panagiotaki et al., 2012; Veraart ...
(Fig.6and Table1). A total of 1052 cases were tested negative for the disorders screened for. There were zero false negative and seven false positive cases (Fig.6). The combined sensitivity and specificity for these disorders were 100% (95% CI, 94.9%–100%) and 99.3% (95% CI, 98.6...
(\pi '\)of countrycat the event timej, and zero if there are no other policies active at that event time. That is, we extend Eq. (2) in two ways: 1) we multiply the event dummies for policy\(\pi \)with the intensity value of the policy at event timej—in other words,\(I[...
(covariance) of the respective state is maintained. For constant loads, the uncertainty of the static loads converges towards zero as time progresses. This means that the performance allocated to the system is increasingly less affected by fluctuations in the measured total power, while dynamic ...