135]. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive subtypes of PC, and late diagnosis and high heterogeneity are the greatest obstacles to its treatment. Despite ongoing efforts to improve the
Middleeastete.net Workers at a construction company in Saudi Arabia have issued an urgent plea for help, saying they are trapped and facing starvation because their employer is refusing to pay salaries or grant them permission to leave the country. Foreign staff at building firm United Seemac to...
The tumor microenvironment is an important concept that defines cancer development not only through tumor cells themselves but also the surrounding cellular and non-cellular components, including stromal cells, blood vessels, infiltrating inflammatory ce
Firstly, there is an urgent need for the systematical identification of hnRNPK-interplayed ncRNAs including lncRNAs, miRNAs and emerging circRNAs. Current research is still scattered, and a more systematic screen may be able to provide a more comprehensive picture of hnRNPK–ncRNAs interaction. To ...
Background: Long non-coding RNAs modulate tumor occurrence through different molecular mechanisms. It had been reported that HNF1A-AS1 (HNF1A Antisense RNA 1) was differently expressed in multiple tumors. The role of HNF1A-AS1 in colorectal cancer was le
Thus, there is an urgent need to identify additional therapeutic targets to improve treatment outcomes in NSCLC. 2. Signal Transducer and Activator of Transcription 3 (STAT3) The Signal Transducer and Activator of Transcription 3 (STAT3) belongs to the STAT family of proteins, which are both ...
Moreover, the elucidation of cellular responses associated with detrimental effects also represent an urgent concern to allow for the further development of aurodrug candidates towards the future transition to the clinic [236,248]. As far as clinical trials are concerned, Auranofin (Figure 6A) has...
Molecular beacons emit fluorescence only when they hybridize with the target, undergoing a spontaneous conformational reorganization that forces the fluorophore and the quencher to move away from each other. This approach is very sensitive to mismatches and, since probes can be linked to different ...
Firstly, there is an urgent need for the systematical identification of hnRNPK-interplayed ncRNAs including lncRNAs, miRNAs and emerging circRNAs. Current research is still scattered, and a more systematic screen may be able to provide a more comprehensive picture of hnRNPK–ncRNAs interaction. To ...