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In situ tumor xenografts were established by injecting the NCI-H1975-luciferase cells or HCC827-luciferase cells (8 × 106) to the lungs of the NOD-SCID mice (6–8 weeks) through the intercostal space during surgical operation under general anesthesia. Doses of ATO and gefitinib to trea...
surgical resection combined with radiotherapy and chemotherapy is still the most effective treatment for advanced BC, but the recurrence rate is still high [158]. With the advancement of technology, other novel therapies, such as molecular targeted ...
abscessus complex infections, which has been also implicated in transmission associated to surgical procedures [359, 360], has stimulated the search for new therapeutic alternatives, such as the use of phage therapy, which opens a window of hope not only for M. abscessus complex but for ...
Despite advances made in HCC treatment, surgical resection is still the main treatment method. However, the prognosis of HCC patients is still not satisfactory, and the reason is mainly due to metastasis and recurrence after surgical removal of the tumor [2]. The exact mechanism of tumor ...
are more relevant to younger AF patients with a genetic predisposition. These models better simulate the progression from paroxysmal AF to persistent AF. Most clinical samples or animal models in literature comprise confirmed AF patients, including those with AF-induced HF or requiring surgical ...
We confirmed this observation by immuno- histochemistry (IHC) assays comparing the FEN1 pro- tein expression level on normal and lung cancer samples from surgical treatment (Fig. 1B). In normal tissue, the proportion of patients with a FEN1 score below 100 was 85% (95% CI, 76–97, P ...
The underlying mechanisms of long non-coding RNAs (lncRNA) participating in the progression of lung cancers are largely unknown. We found a novel lncRNA, PIK3CD antisense RNA 2 (PIK3CD-AS2), that contributes to lung adenocarcinoma (LUAD) progression. The
As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and scientific research, resulting in tumor recurren