Kirsten Rat Sarcoma viral oncogene homolog (KRAS) gene is a gene that produces a protein that functions in the cell signaling systems that regulate cell division, maturation, and growth. It is the most mutated oncogene in human cancers, which hinders the development of effective drugs against KRA...
A case of rapidly fatal small cell sarcoma of kidney in a young woman is described. Histologic, immunohistochemical, and ultrastructural studies demonstrated some features not reported previously in the literature, such as the arrangement of vimentin intermediate filaments in small irregular masses and ...
et al. Ligand-dependent platelet-derived growth factor receptor (PDGFR)-α activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors. Cancer Res. 69, 3937–3946 (2009). Article CAS PubMed PubMed Central Google Scholar Jackson, E. L. et al. Analysis of lung tumor...
DB00570VinblastineA vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
KRAS Kirsten rat sarcoma viral oncogene homolog, ALK anaplastic lymphoma kinase, ROS1 ROS proto-oncogene 1, TKI tyrosine kinase inhibitor, ICIs immune checkpoint inhibitors, ROS reactive oxygen species, HIF hypoxia-inducible factor, Bcl-xL B-cell lymphoma-XL, RASSF1A ras association domain family ...
In human Langerhans cell sarcoma (LCS), TIM-1 could be found in cancer cells, CK-18-positive epithelial cells and CD68-positive macrophages [19]. Liu et al. [20] have also reported that increased TIM-1 expression is found in human gastric cancer tissues compared with the normal gastric ...
[88]. Even so, an involvement of sEV-ncRNAs remains uncertain, although such observations have been made in several other types of tumors. For example, sarcoma and lung tumor cells were shown to induce Treg population through transmission of miRNA-214, while breast cancer cells promote Treg ...
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt pro...
sarcoma and malignant rhabdoid tumours, which both exhibit cBAF complex (SMARCB1 subunit) perturbation. Chemical and biological depletion of the ncBAF subunit, BRD9, rapidly attenuates synovial sarcoma and malignant rhabdoid tumour cell proliferation. Importantly, in cBAF-perturbed cancers, ncBAF ...
Veettil, Mohanan Valiya, et al., “Interaction of c-Cbl with Myosin IIA Regulates Bleb Associated Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus”, PLoS Pathog 6(12): e1001238. doi:10.1371/journal.ppat.1001238, (Dec. 23, 2010), 16 pgs. Wang, Hao, et al., “Role of LAR...