Grades 3 to 4 drug-related toxicity included fatigue (n = 8; 20 %), hypertension (n = 6; 15 %), diarrhea (n = 4; 10 %) elevated transaminases (n = 4; 10 %), gastrointestinal hemorrhage (n = 5; 12.5 %), wound infection (n = 2; 5 %), thrombocytopenia (n = 1; 2.5 %),...
Comorbidities were defined using ICD 10 diagnosis codes, prescription information in the year prior to health screening, and health screening results. The criteria for hypertension were I10–13 or I15 claim codes plus ≥ 1 prescription of an antihypertensive agent, or systolic/diastolic blood ...
Accumulating evidence also suggests that an increase of UPR-related proteins could serve as a prognostic predictor and a candidate for targeted therapy [4–10]. However, the mechanisms by which the UPR mediates the tumorigenesis and NSCLC progression are complex, multifactorial, and remain to be ...
cottoni was shown to be anti-proliferative against oestrogen-dependent MCF-7 and oestrogen-independent MB-MDA-231 human breast-cancer cells in vitro, but non-toxic to non-cancerous cell lines. The extract was fed to female rats and following four weeks of dietary supplementation, mammary ...