Using purified mammalian DNA topoisomerase II, we have demonstrated that the antitumor drugs ellipticine and 2-methyl-9-hydroxyellipticine (2-Me-9-OH-E+) can produce reversible protein-linked DNA breaks in vitro. 2-Me-9-OH-E+ which is more cytotoxic toward L1210 cells and more active ...
The interactions between the natural cyclopentapeptide antibiotic actinomycin D (ACT) and circular pBR322 DNA have been studied by freezing the topological... L.,Leoni,and,... - 《Biophysical Chemistry》 被引量: 1发表: 1989年 Sequence-Specific and Synergistic Binding of Drugs to DNA We had pr...
In the event that one of the drugs or drug combinations reduces the level of virus in the supernatant to below detectable levels while maintaining viable cells in the culture (measured by techniques described in section 11 above), the presence of HIV proviral DNA in the cells is examined. ...
TSPO functions in apoptotic and non-apoptotic processes TSPO, previously known as the peripheral-type benzodiazepine receptor (PBR), is located in the OMM [195]. The receptor is involved in the regulation of cellular proliferation, apoptosis, and mitochondrial functions [196]. Several studies suggest...
Hence, the development of nano drug delivery system loaded with non-apoptotic cell death inducers or other anti-tumor drugs is beneficial to improve therapeutic outcome. In addition, some nanomaterials can also exert anti-tumor effect by influencing the death forms of tumor cells. In general, the...
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To address this, different imaging approaches examined the dynamic nature of microglia in ALS. In vivo positron emission tomography (PET) imaging identified microglial activation in several different regions in ALS patients. Using either 11C-PK11195 or PBR-28, translocator protein radio-ligands that ...
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Medications reported were nonsteroidal anti-inflammatory drugs (NSAIDs). Although four variables did not meet the normal distribution criteria according to the Shapiro-Wilk test and visual inspections, parametric statistical analyses were applied to all variables, as the majority followed a normal ...
These data reveal the complex regulation of NF-κB late in the viral replication cycle, with consequences for both the pathogenesis of HIV/AIDS and the use of NF-κB-modulating drugs in HIV cure strategies. IMPORTANCE The NF-κB pathway regulates host responses to infection and is a common ...