Institutional review boards at the Mayo Clinic and all contributing sites approved the research. All participants provided written informed consent. DNA Sequencing and Bioinformatics Analysis A customized amplicon-based QIASeq panel consisting of 1733 target regions in 37 cancer predisposition genes was ...
The data acquisition took place on everyday-life conditions with a chest belt, meaning the dataset has noisy parts as well as missing data. This makes the dataset ideal for the development and evaluation of algorithms for wearable healthcare systems. The emergence of datasets of this kind is ...
our past studies have also demonstrated the regulatory effect of nerves on bones [170,171]. There is an interesting clinical phenomenon: traumatic brain injury (TBI), one of the most severe types of brain damage, can accelerate bone production, ...
The most widely used scale goes from 0 to 4, 0 meaning there is no fibrosis, whereas 4 equals cirrhosis. The scale is not linear, because both amount and pattern determine the exact stage. So, stage 2 does not mean that you have twice as much scar tissue as in stage 1: there is ...
Meaning In this preliminary study, nonmyeloablative HSCT was more effective than disease-modifying therapy for patients with relapsing-remitting MS. Abstract Importance Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing...
Bar height corresponds to the proportion of simulations in which the active arm had higher rates of treatment response compared to control arm (‘true go rate’) for each early endpoint (x axis), where the left panel shows simulations comparing active ABCP arm to control BCP arm (left panel...
All the data sets are inhibitory, meaning a larger compound dose leads to a smaller response. In the Hand-GP model, we quantify synergy by taking the difference between the response surface (GP fitted to the raw response data) and the null reference model, generated by the Hand construction...
66 day-clinic places, and 9700 cases per year to whom high-frequent out-patient treatment is provided. It is situated in a metropolitan region with a rather low socioeconomic status, socially troubled areas, high rates of immigrants and addiction disorders. Notably, in-patient and day treatment...
Meaning Among patients with nonalcoholic steatohepatitis and obesity, bariatric surgery, compared with nonsurgical management, was associated with a significantly lower risk of incident major adverse liver outcomes and major adverse cardiovascular events. Abstract Importance No therapy has been shown to reduc...
Despite this, PD-L1 expression is far from being a perfect biomarker. First, the screening of the immunotherapy beneficiary population using PD-L1 expression is not entirely accurate. Some patients with high PD-L1 expression do not benefit from ICI therapy in clinic [40,41], while patients who...