Nonmotor symptoms of Parkinson's disease. Expert Rev Neurother. 2006; 6 (12):1811–1822. doi: 10.1586/14737175.6.12.1811. [ Cross Ref ]Zesiewicz TA, Sullivan KL, Hauser RA. Nonmotor symptoms of Parkinson's disease. Expert Rev Neurother. 2006; 6 :1811–22. [ PubMed ]...
Parkinson’s disease is a neurodegenerative disorder of the brain and central nervous system that most people recognize by its motor symptoms, which include tremors, muscle rigidity, impaired balance, and slowness of movement (bradykinesia). Many Parkinson’s patients, however, also develop nonmotor ...
Ever since it was first recognized,1 Parkinson's disease (PD) has been primarily identified by its cardinal motor symptoms: tremor, bradykinesia, muscle rigidity, and gait instability.2 Current therapies act mainly on the dopaminergic system,3 with the overall goal of improving motor symptoms and...
Parkinson’s diseaselt;pgt;The goal of the research was to investigate some non-motor disorders at patients with Parkinson disease (PD) and to determine their relations to the main manifestations of the disease. 68 patients with PD without dementia were studied. Duration of disease was 4 (2-...
传统观点认为帕金森病(Parkinson's disease,PD)是一种单纯的运动障碍性疾病,但近年来PD的非运动症状(non-motor symptoms,NMS)逐渐引起人们的重视。NMS主要分为4类:感觉障碍、睡眠障碍、神经精神障碍、自主神经功能障碍。 NMS可贯穿于PD的始终,在疾病晚期给PD患者带来更为严重的影响,能够加重运动障碍、降低生活质量、...
COPENHAGEN — Giving patients withParkinson's diseaseandconstipationa probiotic for 3 months improved not only their gut microbiome but also nonmotor symptoms such as sleep, fatigue, and constipation, results of a new randomized trial show.
The motor symptoms of Parkinson's disease are generally attributable to loss of striatal dopaminergic neurons, while nonmotor symptoms can be traced to loss of neurons in nondopaminergic regions. Nonmotor symptoms – often including sleep disorders, depression, cognitive changes, and psychosis – may...
Introduction: Parkinson's Disease (PD), a hypo-kinetic movement-disorder constituting of motor symptoms (MS) and non-MS (NMS), but is often solely recognized by characteristic MS namely tremor, rigidity, bradykinesia and a 'shuffling gait.' However recent years have shown an increased a...
Several studies, including work from the Parkinson's disease (PD) non-motor group and others, have established that the non-motor symptoms of PD are common, occur across all stages of PD, are under-reported, and are a key determinant of quality of life. Research suggests that the non-moto...
Parkinson's disease (PD) is a neurodegenerative disorder resulting from degeneration of the substantia nigra and the dopaminergic nigrostriatal pathway. Most treatments are geared toward the management and relief of motor symptoms in Parkinson's patients; however, as the disease progresses, various compl...