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The primary cells affected are dopami- nergic nigrostriatal neurons. Current therapies primarily focus on dopamine replacement and alleviate symptoms but do not alter the underlying progression of disease. The recent clinical trial of GDNF as a disease-modifying therapeutic candidate did not provide ...
The last WHO classifica- tion, released in 2021, also takes into account molecular features, specifically the isocitrate dehydrogenase (IDH) gene mutation status [3]. Aggressive gliomas, which include GBM, harbor wild-type IDH1 and IDH2 genes (IDHwt), whereas gliomas with better prognosis carry...
However, this manifestation may lead to scarring and disfigurement. Based on the infection, one out of ten cases may result in more severe manifestations (known as mucocutaneous leishmaniasis) [63–65]. Similarly, antimony-based drugs were extensively used for schistosomiasis, also a neglected ...