Metal complexes as pharmaceutical agents have been used since early history, but therapeutic efficacy in today's meaning of the term was first confirmed on the basis of the examples of salvarsan (1910), particularly efficient in cases of syphilis, and some organic mercury compounds, such as ...
Heim, M.E., Flechtner, H., Keppler, B.K. (1989). Clinical Studies with Budotitane — A New Non-Platinum Metal Complex for Cancer Therapy. In: Baulieu, E.,et al.Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Progress in Clinical Biochemistry and Medicine, vol 10...
By introducing nanotechnology into photodynamics, the efficacy of photodynamic therapy for bladder cancer has been greatly improved. To improve the resistance and adverse effects of immune checkpoint inhibitors (ICI) during treatment, the immune efficacy of ICI was significantly improved ...
Health care professionals administer the therapy via an IV, and the monoclonal antibodies bind to the cancer cells and augment the immune system's ability to destroy cancer cells. Rituximab (Rituxan) is such a drug used in the treatment of B-cell lymphoma. Side effects for this treatment are...
T cells failed to provide adequate antitumor immune surveillance in NASH-related HCC after immunotherapy.Ιnstead,they triggered the transition to liver cancer through a TNF-dependent mechanism that was further enhanced by anti-PD-1 treatment.Although the study included data from patients with NASH,...
2. Ferroptosis and its inducers for cancer therapy 2.1. The molecular mechanisms of ferroptosis Ferroptosis is a new type of non-apoptotic cell death, which is closely related to the concentration of intracellular ferrous iron (Fe2+) and can be inhibited by iron chelating agents. In 2012, ferro...
On-Demand Drug Release from Gold Nanoturf for a Thermo- and Chemotherapeutic Esophageal Stent Stimuli-responsive delivery systems for cancer therapy have been increasingly used to promote the on-demand therapeutic efficacy of anticancer drugs and, i... L Sori,H Gyoyeon,K Tae Hee,... - 《Acs...
Developing non-metallic contrast agents of clinically applied magnetic resonance imaging (MRI) is an alternative strategy to reduce the toxicity of heavy metal elements in current MRI agents. These non-metallic MRI agents usually generate contrasts by un
The anthraquinone derivative mitoxantrone used in cancer therapy was found to inhibit PknB in M. tuberculosis, thereby preventing its growth [104]. Plant-derived trypsin inhibitors were active against Gram-positive as well as Gram-negative bacteria and exhibited anti-viral activities [105]. AMPKs ...
for cancer therapy. An important advantage of a delivery vector either viral or non-viral is the cumulative ability to penetrate the haphazardly arranged and immunosuppressive tumour microenvironment of solid tumours and or withstand antibody-mediated immune response. Biotechnological approaches incorporating ...