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Lawson RA, Yarnall AJ, Duncan GW, Breen DP, Khoo TK, Williams-Gray CH, Barker RA, Collerton D, Taylor J-P, Burn DJ (2016) Cognitive decline and quality of life in incident Parkinson’s disease: the role of attention. Parkinsonism Relat Disord 27:47–53 PubMed PubMed Central Google ...
The robust and sustained activity of orally-administered PF-2334 in both non-human primate eye blink response and the unilateral 6-OHDA lesioned rodent model of parkinsonism is consistent with the reduced β-arrestin recruitment and desensitization in vitro, and highlights the potential for compounds...
Even though levodopa continues to work against parkinsonism, the dose-by-dose response pattern makes a patient increasingly dependent on the regularity of drug absorption, which becomes increasingly capricious due to PD-related changes occurring in the stomach and upper small intestine. This is ...
(Foffani et al. 2003, 2005c; Priori et al. 2004). In relation to the clinical conditions of the patients, even though the Parkinsonism substantially worsened after overnight withdrawal of levodopa and no patient was on long-acting agonists at the time of surgery, our experimental design ...
Non-invasive imaging of gene expression in live, optically opaque animals is important for multiple applications, including monitoring of genetic circuits and tracking of cell-based therapeutics. Magnetic resonance imaging (MRI) could enable such monitor
Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preference Eur. J. Neurosci., 19 (2004), pp. 437-446, 10.1111/j.0953-816x.2003.03089.x View in ScopusGoogle Scholar Pratt et al., 2012 W.E. Pratt, M.A. Schall, E. Choi...
recruited onto the proteasome upon interaction between their UbLs and the Rpn10 proteasomal subunit [9] [10] [11] and mutations or deletions of the UbL are associated with the loss of the host protein function causing pathological conditions, such as the autosomal recessive juvenile Parkinsonism ...
Another advantage of recording densely sampled time-series data from a force transducer is the ability to explore the dynamics of these data in the frequency domain (Novembre et al.,2019). Cortical oscillations in the β-band (13–30 Hz) have long been associated with motor function. A pr...
The patients in this study were diagnosed with benign tremulous Parkinsonism. This type of Parkinson’s is manifested by the following characteristics: (1) a noticeable RT; (2) symptoms not related to tremor have a confined incidence; (3) predominant lack of gait disorder; and (4) lack of ...