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[21,23–25].SChLAP1, for example, is anlncRNAwith outlier expression in a subset of prostate cancers. It antagonizes the SWI/SNF chromatin-modifying complex, promotes tumor cell invasion andmetastasis, and is strongly associated with aggressive, lethal disease[26,27]. In contrast, while its ...
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat. Med. 13, 1042–1049 (2007). CAS PubMed Google Scholar Kerkhoff, C., Sorg, C., Tandon, N. N. & Nacken, W. Interaction of S100A8/S100A9-arachidonic acid complexes with...
presence of the zinc-binding motif of metalloproteases, the LC of Wo-ORF1 protein also contains the Arg and Tyr residues (residues 369 and 372 of BoNT/B) of the second shell of zinc coordination that are unique of the clostridial metalloproteases family and of the anthrax lethal factor10,25...
(I:C)172or TLR7 with ssRNA168, platelets activate neutrophils to release a chromatin web comprising histones and granular proteins, referred to as a neutrophil extracellular trap (NET). As NETs in SLE are pro-inflammatory, contribute to type I interferon synthesis173and can be a source of ...
Background Cancers of the ovary, cervix and uterus are the common types of gynecological oncology. Ovarian cancer is the most lethal gynecological cancer in women globally. Of which, epithelial ovarian cancer (EOC) is the most common group of ovarian cancers. Based on histopathology, immunohistochem...
Most were returned to the water alive, but at least 20% of these probably suffered lethal damage (Poiner and Harris, 1996). Quantitative data from other regions is sparse, but in Malaysia Chan et al. (1988) estimated that more than 500 turtles of three species (Dermochelys coriacea, ...
Background Cancers of the ovary, cervix and uterus are the common types of gynecological oncology. Ovarian cancer is the most lethal gynecological cancer in women globally. Of which, epithelial ovarian cancer (EOC) is the most common group of ovarian cancers. Based on histopathology, immunohistochem...
The protection efficacies of the MAbs were evaluated in a BALB/c mouse model. Two doses of 10 mg/kg antibody were administrated via intraperitoneal (i.p.) injection 4 h before and 4 h after intranasal (i.n.) challenge of a lethal dose of VACV (Fig. 4a). Control mice were gi...
The Omp85 family of outer membrane proteins are ubiquitously distributed among diderm bacteria and play essential roles in outer membrane (OM) biogenesis. The majority of Omp85 orthologs are bipartite and consist of a conserved OM-embedded 16-stranded be