distribution of other isoforms is confined primarily to stratified epithelial tissue [1–3]. In keeping with its role in tissue integrity, loss of DSG2 function in humans is directly linked to arrhythmogenic right ventricular cardiomyopathy (ARVC), an autosomal recessive disease underpinned by myocyte ...
(Manfrini et al., 2015), some other labs have reported the synthesis of RNAs using the chromatin flanking the break as atemplate(Francia et al., 2012;Wei et al., 2012). Following DNA damage,RNA polymerase IIis recruited directly to DSBs by interacting with the MRN complex and synthesizes...
Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca(2+) leak is independent of diabetic remodeling of myocardium. Biochim. Biophys. Acta Mol. Basis Dis. 1864, 1923–1930 (2018). Article CAS PubMed Google Scholar Gong, W. et al. Amylin deposition in the kidney of patients ...
Antibodies to HIV 1 and 2 were sought using a commercial enzyme-linked immunosorbent assay (ELISA) (Abbott Lab., North Chicago, Ill, USA), with positive results always confirmed by Western blot analysis (Genelabs Diagnostics, Science Park Drive, Singapore); HBsAg, total anti-HBc, and anti-...
Cells were treated with RIPA buffer (Thermo Fisher Scientific) and quantified with the Bio-Rad protein assay kit (Bio-Rad Labs, Richmond, CA, USA). Equal amounts of proteins per sample were separated by sodium dodecyl sulfate–polyacrylamide gel (Thermo Fisher Scientific) electrophoresis and trans...
CardiomyopathyRegenerative medicine stem cellsHeart FailureSurvivalIntroduction:The long-term clinical outcomes of cell-based therapies to treat ischemic (ICM) and non-ischemic dilated cardiomyopathy (NIDCM) are unknown. We therefore prospectively followed patients (pts) with ICM/NICDM treated by targeted...
chronic heart failure; dilated cardiomyopathy; heart failure; left ventricular reverse remodelling; non-ischemic dilated cardiomyopathy1. Introduction Dilated cardiomyopathy (DCM) is defined as the presence of left ventricular or biventricular dilatation and systolic dysfunction that results in heart failure ...
We showed that: (1) the occurrence of VA during EST was more common in the arrhythmic presentation, whereas ischemic manifestations were more prevalent in the nonarrhythmic one; (2) in both arrhythmic and nonarrhythmic groups, adverse events occurred more frequently among patients with abnormal...