TYPE 2 diabetes treatmentPHYSIOLOGICAL adaptationEXERCISEINJECTIONSINSULINMEDICAL personnelORAL drug administrationPATIENT monitoringHEALTH literacyIn the UK the National Institute of Health and Care Excellence
The requirement for delivery by injection is currently a limitation for the use of biologic drugs such as antibodies. In this Review, Mitragotri and colleagues discuss advances made in non-invasive drug delivery for biologics, including the transdermal,
Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover bioma
ACS = acute coronary syndrome; CAD = coronary artery disease; CHD = coronary heart disease; CHF = congestive heart failure; CI = confidence interval; CV = cardiovascular; DM = diabetes mellitus; FBG = fasting blood glucose; Hb = hemoglobin; HR = hazard ratio; IGI = insulin-glucose intraveno...
The organic phase was dried, reconstituted in acetonitrile/isopropanol (1:1), centrifuged, and transferred to vials for UHPLC-MS analysis as described previously.19 An appropriate test mixture of standard compounds was analyzed before and after the entire set of randomized sample injections in order...
The functional state of beta cells may influence the rate of their destruction in Type 1 (insulin-dependent) diabetes mellitus. We examined the effect of diazoxide, which inhibits insulin secretion, or tolbutamide, which stimulates insulin secretion, upon the incidence of diabetes in the non-obese...
Nearly all health professionals, whatever their practice or speciality, now have contact with a significant number of insulin-using people with diabetes. People with type 1 diabetes are nearly unive...
Obesity prevalence has markedly increased worldwide in recent decades1. In addition to its specific comorbidities, obesity is a major risk factor for other metabolic conditions, such as insulin resistance, type 2 diabetes (T2D) mellitus, cardiovascular diseases and certain types of cancer2,3,4. Ob...
Obesity induces insulin resistance, a well-known factor for Type 2 diabetes (T2D), and it is estimated that obesity-related diabetic population will reach 300 million by 20252,3,4,5. The worldwide increase in the incidence of obesity has emerged as a major threat to public health, imposing...
Blocking lymphotoxin: a potential therapy for diabetes? Nonobese diabetic (NOD) mice spontaneously developautoimmune diabetes, bearing close resemblance to the human condition. The disease is mediated by auto-specificT cells, which infiltrate the pancreatic islets and destroy insulin-producing β cells....