TheAnaplastic Lymphoma Kinase(ALK) was originally identified in Anaplastic Large-Cell non-Hodgkin's Lymphoma (ALCL) cell lines as the product of achromosomal translocationt(2;5; p23;q35) involving theNucleophosmin(NPM1) partner[8,9]. The humanALKlocus is located at the 2p23.2–p23.1chromosome...
A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. Biochem. Biophys. Res. Commun. 242: 376 -379.Warzocha et al., " A New Death Receptor 3 Isoform: Expression in Human Lymphoid Cell Lines and Non-Hodgkin's Lymphomas " Biochemical and ...
BTK inhibitor and lenalidomide in treating aggressive B-cell lymphoma has been suggested. Here, the authors report a single-arm phase II clinical trial of combination of acalabrutinib, lenalidomide and rituximab in patients with aggressive Relapsed/Refractory aggressive B-cell non-Hodgkin lymphoma. ...
Non-Hodgkin lymphoma (NHL), the most common hematological malignancy in the world [1,2], mainly (about 86% of NHL) originates from B cells [3]. B-cell NHL (B-NHL) comprises over 40 main subtypes, such as diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), mantle cell l...
AIDS-related non-Hodgkin's lymphoma (AIDS-NHL) is the second most frequent cancer associated with AIDS, and is a frequent cause of death in HIV-infected individuals. Experimental analysis of AIDS-NHL has been facilitated by the availability of an excelle
B-cell non-Hodgkin lymphoma (NHL) collectively represents the most common type of hematologic malignancy [1]. While advances in chemotherapy, monoclonal antibodies, and stem cell transplantation have improved survival rates, many NHL patients remain resistant to therapy or experience relapse. This highl...
Congmin G,Mu Z,Yihui M,et al.Survivin--an attractive target for RNAi in non-Hodgkin‘s lymphoma,Daudi cell line as a model.Leukemia and Lymphoma. 2006Congmin G,Mu Z,Yihui M. Survivin-an attractive target for RNAi in non-Hodgkin's lymphoma,Daudi cell line as a model[J].Leukemia and...
B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of lymphoma and is significantly heterogeneous among various subtypes. Despite of considerable advancements in treatment strategies for B-NHL, the prognosis of relapsed/refractory patients remai
Non-Hodgkin lymphoma is a cancer of the lymphatic system. The lymphatic system contains lymph vessels, lymph nodes, and glands, such as the spleen and thymus. Lymph vessels carry lymph fluid throughout the body. Lymph fluid contains lymphocytes (white blood cells) that help fight infection and...
cell lymphoma cell lines. The cells were treated with Ibrutinib and CHMFL-BTK-85 (maximum concentration 10 μM) for 72 h, and then cell viability was measured using the CellTiter–Glo assay (Error bars, mean ± SEM,n = 3).iThe phosphorylation levels of BTK (Tyr223), PLC...