Radiation therapy has grown up to be an essential tool in the treatment of cancer patients. However, due to biological complexities and heterogeneities, as well as the presence of cancer stem cells (CSCs) [51,52], certain types of tumors are proved to be more resistant to radiation therapy,...
Long non-coding RNAs and chromatin modifiers: their place in the epigenetic code. Epigenetics. 2014;9:21–6. CentralLong non-coding RNAs and chromatin ... FP Marchese,M Huarte - 《Epigenetics》 被引量: 80发表: 2014年 Interplay between long non-coding RNAs and epigenetic machinery: emerging...
The three most common gynaecologic cancers that seriously threaten female lives and health are ovarian cancer, cervical cancer, and endometrial cancer. Glycolysis plays a vital role in gynaecologic cancers. Several long noncoding RNAs (lncRNAs) are known
participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation and regulation of noncoding RNA, especially lncRNA, play a major role in cancer. Generally...
In addition, with normalization to cell number, we detected a significant reduction of hypoxia-induced glucose uptake (Fig. 2e and Supplementary Fig. 6e) and lactate production (Fig. 2f and Supplementary Fig. 6f) in the LncHIFCAR-knockdown SAS cells, suggesting that LncHIFCAR is essential for...
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To balance the dosage of genes in males and females, this lncRNA, which is only expressed from the dormant X chromosome, controls the silence of one X chromosome [85]. XIST's complex and highly regulated interactions with chromatin remodeling factors and epigenetic modifiers make it a key regu...
[53]. Through anti-inflammatory effects in cell models, metformin inhibits the components of the NFκB pathway that are essential for the transformation of stem cells and the formation of cancer stem cells. Metformin also prevents phosphorylation of STAT3 in cancer stem cells [54,55]. The ...
Center for Applied Medical ResearchUniversity of NavarraEpigeneticsMarchese, F. P. & Huarte, M. Long non-coding RNAs and chromatin modifiers. Epigenetics 9, 21-26 (2014).Marchese FP, Huarte M (2014) Long non-coding RNAs and chromatin modifiers: their place in the epigenetic code. ...
These results demonstrated an essential role for miR-342-3p in regulating proliferation and invasion of glioma cells as a direct target for FTX, and also indicated that FTX may have other important targets. The structure of lncRNAs may be complicated, containing several functional domains that can...