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To address this challenge, we developed a unique spatially-targeted and molecularly-specific drug delivery technology by using novel focused ultrasound (FUS) sequences and ultrasound-sensitive drug carriers. First introduced in the 1940s6, FUS allows noninvasive delivery of mechanical energies deep into...
During each visit they assessed the children for sickness espe- cially fever and conducted RDTs on those with fever or suspected to have malaria. Febrile children who tested negative with an RDT were referred to a health facility to validate the result using microscopy. In the interven- tion...
Non-viral gene delivery vectors have to overcome three important barriers during gene delivery: (1) DNA entry across the cell membrane, (2) protection of DNA bound to the vectors and subsequent release of DNA, and (3) DNA entry into the nucleus. Therefore, development of minimally toxic and...
Regarding reproduction, it is a key player not only in the seasonal regulation of sexual activity but also locally by regulating the reproductive organs [4,5], where it possibly acts as a paracrine signal as well as an antioxidant [6]. Many reproductive tissues in the male can produce ...
Alginates from seaweed have also been used as an encapsulation agent for the delivery of probiotics. Alginates are non-toxic, biocompatible, inexpensive to obtain and are easily solubilised in the human intestine facilitating the release of their entrapped cells [168]. Magnesium is in abundant ...
STIM1 then opens ORAI1, a PM channel, which allows Ca2+ entry from the external medium [21–23]. In osteosarcomas, it has been shown that STIM1 upregulation was associated with a CDDP-resistant phenotype [24]. ORAI1 and STIM1 are anti-apoptotic in pancreatic adenocarcinoma cell lines ...
This overlapping arrangement of viral transcripts represents a strategy by which KSHV maximizes its coding capacity and level of gene regulation [28]. 4. Epstein-Barr Virus-Encoded lncRNAs Epstein-Barr virus, which is also known as human herpesvirus-4 (HHV4), is the causative agent of ...
NMP diminishes MCP-1 levels through its regulation of TNF-α. Harmane, norharmane, caffeine, theophylline, trigonelline, and theobromine increase insulin secretion (Figure 4). Harmane and norharmane stimulate imidazoline I3 receptors in pancreatic β-cells, while caffeine enhances insulin secretion;...
The increase of the pore former agent content up to 15 and 20 wt % caused a gradual change in the membrane structure, which became completely symmetric and sponge-like, with the highest employed PEG concentration. These differences reflected also the pore size and the PWP increase up until 1...