The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015;16:413–25. Article CAS PubMed Google Scholar Su DN, Wu SP, Chen HT, He JH. HOTAIR, a long non-coding RNA driver of malignancy whose ...
In this study, we identified that PirB/LILRB2 were expressed in hepatic macrophages and bound with their NASH-associated ligand (ANGPTL8) to trigger the recruitment of macrophages to the liver, providing evidence that the LILRB2/PirB-ANGPTL8 axis could be a pathogenic driver of NASH pathogenesi...
Based on single-cell analysis of MCF10A cells, the NOTCH signaling pathway has been proposed to be another key driver of TGFβ-induced EMT [56]. To date, the most comprehensive resource of information on TGFβ and EMT signaling in MCF10A cells is the work of the Emili group [57]. ...
The world of noncoding RNAs (ncRNAs) has gained widespread attention in recent years due to their novel and crucial potency of biological regulation. Noncoding RNAs play essential regulatory roles in a broad range of developmental processes and diseases,
including development, cell cycle, DNA damage response, senescence, stem cell, self-renewal, and cancer. BMI-1 has recently proven to be of significant clinical relevance as it overexpressed in a number of malignancies22,23,24,25,26,27,28,29,30. We previously identified BMI-1 as a ...
Majority of the human genome is transcribed into RNAs with absent or limited protein-coding potential. microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two major families of the non-protein-coding transcripts. miRNAs and lncRNAs can regulate fund
Long non-coding RNA hotair regulates the proliferation, self-renewal capacity, tumor formation and migration of the cancer stem-like cell (CSC) subpopulation enriched from breast cancer cells. PLoS ONE 2017, 12, e0170860. [CrossRef] [PubMed] 89. Chiyomaru, T.; Yamamura, S.; Fukuhara, S...
This means critical Weberian factors such as renewal, continuity and rational accomplishment [4,21]: (1) Ethics and reputation: "We have this very own choice of ours, based on ethics, social responsibility, something we do not give away . . . so a part of our path must be followed ...
Cells were passaged for <4 months prior to renewal from the frozen stock. MORAb-202 was kindly provided by Eisai Inc. (Cambridge, MA, USA). Eribulin was purchased from Showa University Hospital (Tokyo, Japan). Other chemicals and cell culture media were purchased from FUJIFILM Wako Pure ...
These mechanisms regulate cellular behaviour, such as proliferation and self-renewal of BITCs, differentiation of their progeny, cell survival, stress pathways, migration and invasion, as well as mounting stromal, inflammatory and vascular responses [16]. Examples of molecular networking in brain ...