MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1. Cancer Res 2013; 73: 6046–6055. 28. Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta Stone of a ...
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015;16:413–25. Article CAS PubMed Google Scholar Su DN, Wu SP, Chen HT, He JH. HOTAIR, a long non-coding RNA driver of malignancy whose ...
Based on single-cell analysis of MCF10A cells, the NOTCH signaling pathway has been proposed to be another key driver of TGFβ-induced EMT [56]. To date, the most comprehensive resource of information on TGFβ and EMT signaling in MCF10A cells is the work of the Emili group [57]. ...
Triptolide has also been reported to suppress tumor growth by inhibiting the proliferation and self-renewal of pulmospheres [26]. However, whether it suppresses NSCLC metastasis and the underlying mechanism have not been fully elucidated. Fig. 1: Triptolide restrains the migration and invasion of ...
et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self- renewal. Dev Cell 25, 69–80 (2013). 17. Hou, P. et al. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. ...
2a) and self-renewal on second (Figs. 2b, c) and third passage (data not shown) relative to control cells. To rule out cell type-specific effects, we expanded this analysis to other NSCLC cell lines. Overexpression of SLC25A1 in H1975 or in H1944 cells similarly enhanced CD133 and ...
In this study, we identified that PirB/LILRB2 were expressed in hepatic macrophages and bound with their NASH-associated ligand (ANGPTL8) to trigger the recruitment of macrophages to the liver, providing evidence that the LILRB2/PirB-ANGPTL8 axis could be a pathogenic driver of NASH pathogenesi...
(AT2) cells, which produce surfactants and function as tissue stem cells. If the alveolar epithelium is damaged, AT2 cells undergo self-renewal and differentiate into AT1 cells to regenerate lost alveolar epithelial cells12. Currently, there is growing evidence that non-inflammatory disorders of AT2...
including development, cell cycle, DNA damage response, senescence, stem cell, self-renewal, and cancer. BMI-1 has recently proven to be of significant clinical relevance as it overexpressed in a number of malignancies22,23,24,25,26,27,28,29,30. We previously identified BMI-1 as a ...
The LIN28 family regulates mammalian stem cell self-renewal, and LIN28A in combination with NANOG, OCT4, and SOX2, can reprogram human somatic cells to become pluripotent stem cells32. LIN28A participates in these Scientific Reports | 7:40847 | DOI: 10.1038/srep40847 5 www.nature.com/...