Objective: We investigated immunohistochemical and histological composition of dense and non-dense breast tissue in 18 women undergoing mastectomy as the initial treatment for breast cancer. Materials and Methods: In each mammogram, we l... CD Santos,P Marshall,R Torresan,... - 《Cancer Research...
There were no statistically significant differences in relative expression of Ki-67 (=0.82), ER (=0.09), or PR (=0.96) between dense and non-dense tissue. Consistent with prior reports, we found that mammographically dense areas of the breast differ histologically from non-dense areas, ...
Mammographic density is a strong risk factor for breast cancer but its underlying biology in healthy women is not well-defined. Using a novel collection of
digital breast tomosynthesisdense breastBACKGROUND. Women's breast cancer is considered a serious public health issue. throughout the world. For asymptomatic women, digital mammography is the primary imaging modality used for breast cancer screening. It also has been shown to reduce breast cancer ...
Genetic studies have associated thousands of enhancers with breast cancer (BC). However, the vast majority have not been functionally characterized. Thus, it remains unclear how BC-associated enhancers contribute to cancer. Here, we perform single-cell C
13-55 ). The “coffee bean” sign refers to the inverted U shape of the sigmoid colon with a dense white line formed by the apposed colonic walls, which is directed from the pelvis to the right upper quadrant. A single contrast enema typically reveals a smoothly tapered narrowing of the...
Our results also highlight a dense SNV hotspot in the widely-studied NEAT1 oncogene. To directly evaluate the functional significance of NEAT1 SNVs, we use in cellulo mutagenesis to introduce tumour-like mutations in the gene and observe a significant and reproducible increase in cell fitness, ...
Superficial and deep, dense perivascular lymphocytic infiltrate. The lesions may attain considerable size (up to 10 cm across) over a period of several weeks, may be mildly pruritic, and have a predilection for the trunk and proximal extremities. Most cases resolve spontaneously within 6 weeks; ...
Almonertinib is the initial third-generation EGFR-TKI in China, but its resistance mechanism is unknown. Cancer-associated fibroblasts (CAFs) are essential matrix components in the tumor microenvironment, but their impact on almonertinib resistance is un
The role of Vimentin in Regulating Cell Invasive Migration in Dense Cultures of Breast Carcinoma Cells. Nano Lett. 2017;17:6941–8. Article CAS PubMed Google Scholar Wang W, Yi M, Zhang R, Li J, Chen S, Cai J, et al. Vimentin is a crucial target for anti-metastasis therapy of ...